Longitudinal study in HIV/HCV-coinfected HAART-naive patients and role of HCV genotype

To evaluate the impact of highly active antiretroviral therapy (HAART) on the course of hepatitis C (HCV) infection, we studied the biological and virological characteristics of 23 HCV/HIV-coinfected HAART-naive patients. The HCV genotype, HCV and HIV viral loads, serum alanine aminotransferase, CD4...

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Bibliographic Details
Published in:Journal of clinical virology 2005-02, Vol.32 (2), p.151-155
Main Authors: Caudai, C., Pianese, M., Zacchini, F., Toti, M., Zazzi, M., Valensin, P.E.
Format: Article
Language:English
Subjects:
Adult
Alanine Transaminase - metabolism
Antiretroviral Therapy, Highly Active
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Female
Genotype
HAART
HCV genotype
HCV-RNA
HCV/HIV coinfection
Hepacivirus - classification
Hepacivirus - genetics
Hepacivirus - isolation & purification
Hepatitis C - complications
Hepatitis C - drug therapy
Hepatitis C - immunology
Hepatitis C - virology
Hepatitis C virus
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - virology
HIV-1 - physiology
HIV-RNA
Human immunodeficiency virus
Humans
Longitudinal Studies
Lymphocyte Count
Male
RNA, Viral - blood
Viral Load
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Summary:To evaluate the impact of highly active antiretroviral therapy (HAART) on the course of hepatitis C (HCV) infection, we studied the biological and virological characteristics of 23 HCV/HIV-coinfected HAART-naive patients. The HCV genotype, HCV and HIV viral loads, serum alanine aminotransferase, CD4 +and CD8 + cell/mm 3 were determined at baseline, 1 month, 6 months and 12 months after initiation of HAART. Results were analyzed both in terms of total population and of HCV genotype. The study of the total population suggests that this therapy did not determine a significant alteration of HCV viremia and levels of ALT, while a significant decrease in HIV viremia (−1.7 log 10 at one year from the start of HAART) and increase in CD4 + counts was observed ( P < 0.005). The biological and virological parameters of HCV/HIV coinfection differed according to the HCV genotype. In particular, only genotype 4 showed a significant inverse correlation between HCV and HIV viral loads.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2004.05.005