Clinical Considerations on Sentinel Node Biopsy in Melanoma from an Italian Multicentric Study on 1,313 Patients (SOLISM–IMI)

Background Although widely used for the management of patients with cutaneous melanoma, the sentinel lymph node (SLN) biopsy (SNB) procedure raises several issues. This study was designed to investigate: the predictive factors of SLN status, the false-negative (FN) rate, and patients’ prognosis afte...

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Bibliographic Details
Published in:Annals of surgical oncology 2009-07, Vol.16 (7), p.2018-2027
Main Authors: Testori, Alessandro, De Salvo, Gian Luca, Montesco, Maria Cristina, Trifirò, Giuseppe, Mocellin, Simone, Landi, Giorgio, Macripò, Giuseppe, Carcoforo, Paolo, Ricotti, Giuseppe, Giudice, Giuseppe, Picciotto, Franco, Donner, Davide, Di Filippo, Franco, Soteldo, Javier, Casara, Dario, Schiavon, Mauro, Vecchiato, Antonella, Pasquali, Sandro, Baldini, Federica, Mazzarol, Giovanni, Rossi, Carlo Riccardo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
False Negative Reactions
Female
Humans
Italy
Lymph Nodes - pathology
Male
Medicine
Medicine & Public Health
Melanoma - mortality
Melanoma - pathology
Melanomas
Middle Aged
Oncology
Predictive Value of Tests
Prognosis
Sentinel Lymph Node Biopsy
Skin Neoplasms - mortality
Skin Neoplasms - pathology
Surgery
Surgical Oncology
Young Adult
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Summary:Background Although widely used for the management of patients with cutaneous melanoma, the sentinel lymph node (SLN) biopsy (SNB) procedure raises several issues. This study was designed to investigate: the predictive factors of SLN status, the false-negative (FN) rate, and patients’ prognosis after SNB. Patients and Methods This is an observational, prospective study conducted on a large series of consecutive patients ( n  = 1,313) enrolled by 23 Italian centers from 2000 through 2002. A commonly shared protocol was adopted for the SNB surgical procedure and the SLN pathological examination. Results The SLN positive and false-negative (FN) rates were 16.9% and 14.4%, respectively (median follow-up, 4.5 years). At multivariable logistic regression analysis, the frequency of positive SLN increased with increasing Breslow thickness ( p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-008-0273-8