Left ventricular mass increase is associated with cognitive decline and dementia in the elderly independently of blood pressure

Aims Left ventricular (LV) mass increase is considered part of composite target organ damage in hypertension and an independent risk factor for cardiovascular (CV) events. This study was designed to explore whether left ventricular mass index (LVMI) is associated with cognitive decline and dementia...

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Bibliographic Details
Published in:European heart journal 2009-06, Vol.30 (12), p.1525-1529
Main Authors: Scuteri, Angelo, Coluccia, Roberta, Castello, Lorenzo, Nevola, Edoardo, Brancati, Anna Maria, Volpe, Massimo
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Antihypertensive Agents - therapeutic use
Arterial stiffness
Biological and medical sciences
Blood Flow Velocity - physiology
Blood pressure
Blood Pressure - physiology
Cardiology. Vascular system
Carotid Arteries - physiopathology
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - physiopathology
Cognition
Cognition Disorders - etiology
Dementia
Dementia - etiology
Dementia - physiopathology
Diabetes Mellitus - physiopathology
Elasticity
Elderly
Female
Humans
Hypertension - complications
Hypertension - drug therapy
Hypertrophy, Left Ventricular - complications
Hypertrophy, Left Ventricular - diagnostic imaging
Hypertrophy, Left Ventricular - physiopathology
Left ventricular mass
Logistic Models
Male
Medical sciences
Middle Aged
Prevalence
Pulse
Pulse wave velocity
Ultrasonography
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Summary:Aims Left ventricular (LV) mass increase is considered part of composite target organ damage in hypertension and an independent risk factor for cardiovascular (CV) events. This study was designed to explore whether left ventricular mass index (LVMI) is associated with cognitive decline and dementia in elderly subjects, independently of blood pressure (BP) levels. Methods and results Four hundred subjects (mean age 79 ± 6 years) were studied. Left ventricular mass was measured echocardiographically in accordance with American Society of Echocardiography and normalized for body height to the 2.7 (LVMI). Global cognitive function was evaluated with the mini-mental state examination (MMSE) (maximum score 30). Dementia was defined as an MMSE score
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehp133