Chaperones and slow death – a recipe for tumor immunotherapy

In an exciting recent paper Richard Vile and coworkers describe a novel approach to tumor immunotherapy based on the killing of a population of normal cells within an inflammatory environment. This approach builds on recent studies showing that the molecular chaperone Hsp70 can act at multiple stage...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2005-02, Vol.23 (2), p.57-59
Main Author: Calderwood, Stuart K.
Format: Article
Language:English
Subjects:
Animals
Autoimmunity
Biological and medical sciences
Biotechnology
CD8-Positive T-Lymphocytes - immunology
Cell Death - immunology
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
HSP70 Heat-Shock Proteins - immunology
Humans
Immunotherapy
Industrial applications and implications. Economical aspects
Melanocytes - immunology
Melanoma - immunology
Melanoma - therapy
Miscellaneous
Molecular Chaperones - immunology
Neoplasms - immunology
Neoplasms - pathology
Neoplasms - therapy
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Summary:In an exciting recent paper Richard Vile and coworkers describe a novel approach to tumor immunotherapy based on the killing of a population of normal cells within an inflammatory environment. This approach builds on recent studies showing that the molecular chaperone Hsp70 can act at multiple stages during tumor antigen presentation to enhance the generation of CD8 + T lymphocyte-mediated immunity and lead to regression of primary and metastatic tumors.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2004.12.011