Immune-mediated and chronic inflammatory disease in people with sarcoidosis: disease associations in a large UK database

Background:Sarcoidosis is a multi-system disorder characterised by non-caseating granulomas. Coexistence of sarcoidosis with immune-mediated and chronic inflammatory diseases has been described in case series. However, the coexistence of two different diseases in individuals can occur by chance, eve...

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Bibliographic Details
Published in:Postgraduate medical journal 2009-05, Vol.85 (1003), p.233-237
Main Authors: Rajoriya, N, Wotton, C J, Yeates, D G R, Travis, S P L, Goldacre, M J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age groups
Aged
Aged, 80 and over
Biological and medical sciences
Child
Child, Preschool
Chronic Disease
Cohort Studies
Crohns disease
Data collection
Day Care, Medical
General aspects
Hospitalization
Hospitals
Humans
Immune System Diseases - complications
Immune System Diseases - epidemiology
immune-mediated
Infant
Inflammation - complications
Inflammation - epidemiology
inflammatory disease
Inflammatory diseases
Joint surgery
Medical sciences
Middle Aged
Patients
Sarcoidosis
Sarcoidosis - complications
Sarcoidosis - epidemiology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
United Kingdom - epidemiology
Young Adult
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Summary:Background:Sarcoidosis is a multi-system disorder characterised by non-caseating granulomas. Coexistence of sarcoidosis with immune-mediated and chronic inflammatory diseases has been described in case series. However, the coexistence of two different diseases in individuals can occur by chance, even if each of the diseases is rare.Aim:To determine whether sarcoidosis necessitating hospital admission or day-case care coexists with a range of immune-mediated and chronic inflammatory diseases more commonly than expected by chance.Design:Analysis of an epidemiological database of hospital admission and day-case statistics, spanning 30 years.Results:1510 patients with sarcoidosis were identified (mean age 44 years, median follow-up 19 years) who had been admitted to hospital or day-case care. Significant associations in the sarcoidosis cohort were identified with systemic lupus erythematosus (odds ratio (OR) 8.3; 95% CI 2.7 to 19.4), autoimmune chronic hepatitis (OR 6.7; 95% CI 1.8 to 17.1), multiple sclerosis (OR 3.3; 95% CI 1.7 to 5.6), coeliac disease (OR 3.1; 95% CI 1.01 to 7.3), thyrotoxicosis (OR 2.5; 95% CI 1.4 to 4.0), myxoedema (OR 2.2; 95% CI 1.2 to 3.7) and ulcerative colitis (OR 2.1; 95% CI 1.1 to 3.7). Weaker associations were found for diabetes mellitus with a first admission aged 30–49 years (OR 2.9; 95% CI 2.1 to 4.0) or age >50 (OR 1.7; 95% CI 1.2 to 2.3), but not for people age
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.2008.067769