Reduced insulin sensitivity and the presence of cardiovascular risk factors in short prepubertal children born small for gestational age (SGA)

Summary Background  Epidemiological studies have shown that the metabolic syndrome, a combination of type 2 diabetes mellitus, hypertension, dyslipidaemia and a high body mass index (BMI), occurs more frequently among adults who were born with a low birth weight. Because insulin is thought to play a...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2005-01, Vol.62 (1), p.44-50
Main Authors: Arends, N. J. T., Boonstra, V. H., Duivenvoorden, H. J., Hofman, P. L., Cutfield, W. S., Hokken-Koelega, A. C. S.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiovascular Diseases - etiology
Cardiovascular Diseases - metabolism
Case-Control Studies
Child
Cluster Analysis
Diabetes Mellitus, Type 2 - etiology
Diabetes Mellitus, Type 2 - metabolism
Endocrinopathies
Fatty Acids, Nonesterified - blood
Female
Fundamental and applied biological sciences. Psychology
Glucose
Glucose Tolerance Test
Growth Disorders - metabolism
Humans
Infant, Newborn
Infant, Small for Gestational Age
Insulin - blood
Insulin Resistance
Male
Medical sciences
Risk Factors
Vertebrates: endocrinology
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Summary:Summary Background  Epidemiological studies have shown that the metabolic syndrome, a combination of type 2 diabetes mellitus, hypertension, dyslipidaemia and a high body mass index (BMI), occurs more frequently among adults who were born with a low birth weight. Because insulin is thought to play a key role in the pathogenesis of this syndrome we investigated insulin sensitivity and risk factors for cardiovascular disease in short prepubertal children born small for gestational age (SGA). Patients and Methods  Frequently sampled intravenous glucose tolerance tests (FSIGT) were performed in 28 short prepubertal children born SGA. Short stature was defined as a height < –2SD. SGA was defined as a birth length and/or a birth weight for gestational age 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2004.02171.x