Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system

A vast literature exists on the biology of blood formation and regeneration under experimental and clinical conditions. The field of hematopoiesis was recently advanced by the capacity to purify to homogeneity primitive hematopoietic stem and progenitor cells. Isolation of cells at defined maturatio...

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Bibliographic Details
Published in:Annual review of medicine 2005-01, Vol.56 (1), p.509-538
Main Authors: Shizuru, Judith A, Negrin, Robert S, Weissman, Irving L
Format: Article
Language:English
Subjects:
Animals
Antigens, CD34 - analysis
Autoimmune Diseases - immunology
Autoimmune Diseases - therapy
Bone marrow
Cancer
Cell Differentiation - physiology
Cell Separation
Cell Transformation, Neoplastic - metabolism
Hematology
Hematopoiesis - physiology
Hematopoietic Stem Cells - physiology
Humans
Immune Tolerance - immunology
Lymphatic System - physiology
Multipotent Stem Cells - physiology
Regeneration - physiology
Rodents
Stem cells
Transplantation, Homologous
Transplants & implants
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Summary:A vast literature exists on the biology of blood formation and regeneration under experimental and clinical conditions. The field of hematopoiesis was recently advanced by the capacity to purify to homogeneity primitive hematopoietic stem and progenitor cells. Isolation of cells at defined maturational stages has enhanced the understanding of the fundamental nature of stem cells, including how cell fate decisions are made, and this understanding is relevant to the development of other normal as well as malignant tissues. This review updates the basic biology of hematopoietic stem cells (HSC) and progenitors, the evolving use of purified HSC as grafts for clinical hematopoietic cell transplantation (HCT) including immune tolerance induction, and the application of HSC biology to other stem cell fields.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev.med.54.101601.152334