Intronic microRNAs

MicroRNAs (miRNAs), small single-stranded regulatory RNAs capable of interfering with intracellular mRNAs that contain partial complementarity, are useful for the design of new therapies against cancer polymorphism and viral mutation. MiRNA was originally discovered in the intergenic regions of the...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2005-01, Vol.326 (3), p.515-520
Main Authors: Ying, Shao-Yao, Lin, Shi-Lung
Format: Article
Language:English
Subjects:
Caenorhabditis elegans
Functional/structural genomics
Gene expression
Gene Expression Regulation - physiology
Genetic regulation
Humans
Intronic microRNA
Introns - physiology
MicroRNA
MicroRNAs - biosynthesis
MicroRNAs - physiology
MicroRNAs - therapeutic use
Neoplasms - therapy
Posttranslational modification
Regulatory gene
RNA biosynthesis
Virus Diseases - therapy
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Summary:MicroRNAs (miRNAs), small single-stranded regulatory RNAs capable of interfering with intracellular mRNAs that contain partial complementarity, are useful for the design of new therapies against cancer polymorphism and viral mutation. MiRNA was originally discovered in the intergenic regions of the Caenorhabditis elegans genome as native RNA fragments that modulate a wide range of genetic regulatory pathways during animal development. However, neither RNA promoter nor polymerase responsible for miRNA biogenesis was determined. Recent findings of intron-derived miRNA in C. elegans, mouse, and human have inevitably led to an alternative pathway for miRNA biogenesis, which relies on the coupled interaction of Pol-II-mediated pre-mRNA transcription and intron excision, occurring in certain nuclear regions proximal to genomic perichromatin fibrils.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2004.10.215