Influence of Host Genetic Variation on Susceptibility to HIV Type 1 Infection

For this review of genetic susceptibility to human immunodeficiency virus type 1 infection, far more information was available on factors involved in acquisition of the virus by an uninfected “recipient” than on propagation by the infected “donor.” Genetic variation presumably alters transmission fr...

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Bibliographic Details
Published in:The Journal of infectious diseases 2005-02, Vol.191 (Supplement-1), p.S68-S77
Main Authors: Kaslow, Richard A., Dorak, Tevfik, Tang, James (Jianming)
Format: Article
Language:English
Subjects:
AIDS
Alleles
Biological Determinants, Vaccines, and Antiviral Therapy
Chemokines, CXC - genetics
Genetic Predisposition to Disease
HIV
HIV 1
HIV Infections - genetics
HLA antigens
HLA Antigens - genetics
Human genetics
Human immunodeficiency virus 1
Humans
Infections
Medical genetics
Polymorphism, Genetic
Receptors
Viruses
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Summary:For this review of genetic susceptibility to human immunodeficiency virus type 1 infection, far more information was available on factors involved in acquisition of the virus by an uninfected “recipient” than on propagation by the infected “donor.” Genetic variation presumably alters transmission from an infected host primarily by regulating the replication of virus and the concentration of particles circulating in blood and mucosal secretions of the potential donor. Thus, the effects of host genetic variation on transmission are inextricably bound to the well-established and powerful effects on virus load at different stages of infection. Teasing apart the effects in both donors and recipients has been and will continue to be quite difficult
ISSN:0022-1899
1537-6613
DOI:10.1086/425269