N-Terminal Pro-B-Type Natriuretic Peptide as an Indicator of Possible Cardiovascular Disease in Severely Obese Individuals: Comparison with Patients in Different Stages of Heart Failure

Mild stages of heart failure might be difficult to diagnose in severely obese individuals with a body mass index (BMI) >40 kg/m(2). Measurement of the N-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP) is feasible for detecting cardiac impairment. The aims of our study were to meas...

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Bibliographic Details
Published in:Clinical chemistry (Baltimore, Md.) Md.), 2005-01, Vol.51 (1), p.138-143
Main Authors: Hermann-Arnhof, Katharina-Maria, Hanusch-Enserer, Ursula, Kaestenbauer, Thomas, Publig, Thomas, Dunky, Attila, Rosen, Harald R, Prager, Rudolf, Koller, Ursula
Format: Article
Language:English
Subjects:
Adult
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Biomarkers - blood
Cross-Sectional Studies
Female
Fundamental and applied biological sciences. Psychology
Heart Failure - blood
Heart Failure - diagnosis
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Natriuretic Peptide, Brain
Nerve Tissue Proteins - blood
Obesity - blood
Peptide Fragments - blood
Protein Precursors - blood
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Summary:Mild stages of heart failure might be difficult to diagnose in severely obese individuals with a body mass index (BMI) >40 kg/m(2). Measurement of the N-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP) is feasible for detecting cardiac impairment. The aims of our study were to measure NT-proBNP in plasma of severely obese patients and to compare the results with results for patients in different stages of manifest cardiac dysfunction. In 61 severely obese individuals (median BMI, 43.2 kg/m(2)) and 96 nonobese patients with existing heart failure [classified into New York Heart Association (NYHA) classes I-IV], NT-proBNP was measured in the fasting condition. A medical history, physical examination, electrocardiography, blood chemistry, and chest x-ray were performed in the obese group. In addition, echocardiography was performed in the NYHA group. In obese individuals, NT-proBNP was increased to a median of 356 (interquartile range, 221-458) pmol/L [854 (530-1099) ng/L] and was comparable (P >0.05) to the median value for NYHA I patients {289 (258-451) pmol/L [694 (619-1082) ng/L]}, but was significantly lower than in the other NYHA groups (P
ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2004.035923