Serum estrogen level after hormone replacement therapy and body mass index in postmenopausal and bilaterally ovariectomized women

Objective: The objective of this study was to determine the relationships of serum estrogen levels after hormone replacement therapy (HRT) every other day and every day with body mass index (BMI) in postmenopausal and bilaterally ovariectomized women. Methods: Eighty-six postmenopausal and 51 bilate...

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Bibliographic Details
Published in:Maturitas 2005-01, Vol.50 (1), p.19-29
Main Authors: Yasui, Toshiyuki, Uemura, Hirokazu, Umino, Yuka, Takikawa, Masaya, Saito, Seiichiro, Kuwahara, Akira, Matsuzaki, Toshiya, Maegawa, Masahiko, Furumoto, Hiroyuki, Miura, Masakazu, Irahara, Minoru
Format: Article
Language:English
Subjects:
Administration, Oral
Biological and medical sciences
Body Mass Index
Contraceptive Agents, Female - therapeutic use
Drug Administration Schedule
Estradiol - blood
Estrogen Replacement Therapy
Estrogens - therapeutic use
Estrogens, Conjugated (USP) - therapeutic use
Estrone - blood
Female
Genital system. Reproduction
Gynecology. Andrology. Obstetrics
Hormone replacement therapy
Humans
Medical sciences
Medroxyprogesterone Acetate - therapeutic use
Middle Aged
Ovariectomized women
Ovariectomy
Pharmacology. Drug treatments
Postmenopause
Puberal and climacteric disorders (male and female)
Serum estrogen level
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Summary:Objective: The objective of this study was to determine the relationships of serum estrogen levels after hormone replacement therapy (HRT) every other day and every day with body mass index (BMI) in postmenopausal and bilaterally ovariectomized women. Methods: Eighty-six postmenopausal and 51 bilaterally ovariectomized women who had been suffering from vasomotor symptoms such as hot flush or atrophy of the vagina were randomly treated with HRT every other day or every day. Seventy-four patients received oral administration of 0.625 mg conjugated equine estrogen (CEE) and 2.5 mg medroxyprogesterone acetate (MPA) every other day, and 63 patients received oral administration of 0.625 mg CEE and 2.5 mg MPA every day as conventional HRT. Results: Eighty-four postmenopausal and 50 bilaterally ovariectomized women completed this study. Serum estradiol levels after HRT every day in postmenopausal and bilaterally ovariectomized women were significantly ( P
ISSN:0378-5122
1873-4111
DOI:10.1016/j.maturitas.2004.03.013