Obstetric outcomes following vitrification of in vitro and in vivo matured oocytes

Objective To evaluate obstetric outcomes with oocyte vitrification after ovarian stimulation (OS) and in vitro maturation (IVM) of immature oocytes. Design A prospective trial from October 2003 to April 2007. Setting University-based medical center. Patient(s) OS group: 38 patients undergoing intrau...

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Bibliographic Details
Published in:	Fertility and sterility 2009-06, Vol.91 (6), p.2391-2398
Main Authors:	Chian, Ri-Cheng, Ph.D, Huang, Jack Y.J., M.D, Gilbert, Lucy, M.D, Son, Weon-Young, Ph.D, Holzer, Hananel, M.D, Cui, Shan Jin, B.M, Buckett, William M., M.D, Tulandi, Togas, M.D., M.H.C.M, Tan, Seang Lin, M.D., M.B.A
Format:	Article
Language:	eng
Subjects:	Biological and medical sciences Cell Survival cryopreservation Cryopreservation - methods Delivery. Postpartum. Lactation Embryo Transfer - methods Female fertility preservation Fertilization Fertilization in Vitro - methods Gynecology. Andrology. Obstetrics Humans in vitro maturation Infertility, Female - epidemiology Infertility, Male - epidemiology Internal Medicine live birth Male Medical sciences Obstetrics and Gynecology Oocyte Oocyte Retrieval Oocytes - cytology Oocytes - physiology Organ Preservation - methods Pregnancy Pregnancy Outcome - epidemiology Prospective Studies vitrification
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Summary:	Objective To evaluate obstetric outcomes with oocyte vitrification after ovarian stimulation (OS) and in vitro maturation (IVM) of immature oocytes. Design A prospective trial from October 2003 to April 2007. Setting University-based medical center. Patient(s) OS group: 38 patients undergoing intrauterine insemination who overresponded to OS. IVM group: 20 patients who had previous unsuccessful intrauterine insemination. Intervention(s) Mature oocyte retrieval following OS. Immature oocyte retrieval and IVM. Oocyte vitrification, thawing, insemination, and transfer of the resulting embryos. Main Outcome Measure(s) Live-birth rates and obstetric outcomes. Result(s) The OS group was superior to the IVM group in terms of oocyte survival (81.4 ± 22.6% vs. 67.5 ± 26.1%), fertilization rate (75.6 ± 22.5% vs. 64.2 ± 19.9%), and cumulative embryo score (38.4 ± 22.3 vs. 20.0 ± 13.8). However, the differences in the implantation rate per embryo (19.1 ± 25.8% vs. 9.6 ± 24.1%), clinical pregnancy rate per cycle started (44.7%, vs. 20.0%), and live-birth rate per cycle started (39.5% vs. 20.0%) were not statistically significant. Twenty healthy babies were born in the OS group and four in the IVM group. Conclusion(s) Pregnancies achieved with vitrification of oocytes after OS and IVM treatments do not appear to be associated with adverse pregnancy outcomes. Vitrification of IVM oocytes represents a novel option for fertility preservation.
ISSN:	0015-0282 1556-5653