Parameters of Inflammation in Morbid Obesity: Lack of Effect of Moderate Weight Loss

Background Obesity has been associated with a chronic activation of the acute-phase response. The aims of our study were to investigate whether levels of inflammatory cytokines are higher in obese patients, to evaluate their relationship with metabolic syndrome, and to analyze the effect of moderate...

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Bibliographic Details
Published in:Obesity surgery 2009-05, Vol.19 (5), p.571-576
Main Authors: Solá, Eva, Jover, Ana, López-Ruiz, Antonio, Jarabo, María, Vayá, Amparo, Morillas, Carlos, Gómez-Balaguer, Marcelino, Hernández-Mijares, Antonio
Format: Article
Language:English
Subjects:
Acute-Phase Proteins - metabolism
Adolescent
Adult
Biomarkers - blood
Caloric Restriction
Case-Control Studies
Cohort Studies
Cytokines
Diet
Female
Humans
Inflammation - blood
Interleukin-6 - blood
Leukocyte Count
Male
Medicine
Medicine & Public Health
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - epidemiology
Middle Aged
Morbidity
Obesity
Obesity, Morbid - blood
Obesity, Morbid - diet therapy
Obesity, Morbid - pathology
Research Article
Surgery
Tumor Necrosis Factor-alpha - blood
Weight control
Weight Loss - physiology
Young Adult
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Summary:Background Obesity has been associated with a chronic activation of the acute-phase response. The aims of our study were to investigate whether levels of inflammatory cytokines are higher in obese patients, to evaluate their relationship with metabolic syndrome, and to analyze the effect of moderate weight loss upon their levels. Methods Sixty-seven severe or morbid obese patients were compared with 67 controls. Patients were submitted to a 4-week very low calorie diet followed by a low calorie diet for 2 months. Exclusion criteria were organic disease, ischemic heart disease or stroke, diabetes mellitus, hyperlipidemia, and hypertension. An evaluation was performed before and after the diet, in which fibrinogen, blood count, high-sensitive C-reactive protein (CRP), interleukin 6 (IL-6), and tumoral necrosis factor α (TNF-α) were measured. The Student t test was employed to compare differences between the groups and Pearson correlation coefficients were calculated. Results Obese patients showed higher levels of CRP ( P  
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-008-9772-8