Severe Cerebral White Matter Hyperintensities Predict Severe Cognitive Decline in Patients With Cerebrovascular Disease History

Cerebral white matter hyperintensities (WMHs) are believed to be the consequence of small vessel disease, and it is uncertain whether their extent predicts the risk of dementia in patients with vascular disease history. Method- Brain MRI was performed in 226 participants of the PROGRESS study. WMH s...

Full description

Saved in:
Bibliographic Details
Published in:Stroke (1970) 2009-06, Vol.40 (6), p.2219-2221
Main Authors: DUFOUIL, Carole, GODIN, Ophélia, CHALMERS, John, COSKUN, Oghuzan, MACMAHON, Stephen, TZOURIO-MAZOYER, Nathalie, BOUSSER, Marie-Germaine, ANDERSON, Craig, MAZOYER, Bernard, TZOURIO, Christophe
Format: Article
Language:English
Subjects:
Aged
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Biological and medical sciences
Brain - pathology
Cerebrovascular Disorders - pathology
Cerebrovascular Disorders - psychology
Cognition Disorders - pathology
Cognition Disorders - psychology
Dementia - pathology
Dementia - psychology
Disease Progression
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Female
Follow-Up Studies
Humans
Ischemic Attack, Transient - pathology
Ischemic Attack, Transient - psychology
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Neuropsychological Tests
Perindopril - therapeutic use
Predictive Value of Tests
Recurrence
Stroke - pathology
Stroke - psychology
Vascular diseases and vascular malformations of the nervous system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cerebral white matter hyperintensities (WMHs) are believed to be the consequence of small vessel disease, and it is uncertain whether their extent predicts the risk of dementia in patients with vascular disease history. Method- Brain MRI was performed in 226 participants of the PROGRESS study. WMH severity was assessed using a visual rating scale. During follow-up, patients were classified for incident severe cognitive deterioration (including dementia) using standard criteria. Over 4-year follow-up, the incidence of severe cognitive deterioration ranged from 1.1 to 9.1 per 100 person-years in patients with respectively no or severe WMHs at baseline. In multivariable analysis, incident severe cognitive deterioration was associated with baseline severe WMHs (odds ratio=7.7, P
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.108.540633