Experimental Evaluation of a New Antithrombogenic Stent Using Ion Beam Surface Modification

A new antithrombogenic stent using ion beam surface modification nanotechnology was evaluated. The ion stent is being developed to inhibit acute and chronic stent‐related thrombosis. Thirty self‐expanding mesh stents were fabricated from Ti‐Ni metal wires with a dimension of 4 mm (diameter) × 25 mm...

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Bibliographic Details
Published in:Artificial organs 2009-06, Vol.33 (6), p.456-463
Main Authors: Sugita, Yoichi, Suzuki, Yoshiaki, Someya, Kenji, Ogawa, Akira, Furuhata, Hiroshi, Miyoshi, Shinichiro, Motomura, Tadashi, Miyamoto, Hiroshi, Igo, Stephen, Nosé, Yukihiko
Format: Article
Language:English
Subjects:
Animals
Blood Platelets - cytology
Blood Platelets - drug effects
Blood Vessel Prosthesis Implantation
Cations, Monovalent - chemistry
Cations, Monovalent - pharmacology
Cell Adhesion - drug effects
Cerebral stent
Coated Materials, Biocompatible - chemistry
Coated Materials, Biocompatible - pharmacology
Collagen
Collagen Type I - chemistry
Collagen Type I - pharmacology
Coronary stent
Dogs
Endothelial Cells - cytology
Endothelial Cells - drug effects
Helium - chemistry
Helium - pharmacology
Ion beam surface modification
Materials Testing
Neointima
Nickel - chemistry
Stents - adverse effects
Thrombosis - etiology
Thrombosis - therapy
Time Factors
Titanium - chemistry
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Summary:A new antithrombogenic stent using ion beam surface modification nanotechnology was evaluated. The ion stent is being developed to inhibit acute and chronic stent‐related thrombosis. Thirty self‐expanding mesh stents were fabricated from Ti‐Ni metal wires with a dimension of 4 mm (diameter) × 25 mm (length) × 0.15 mm (thickness). Twenty stents were coated with type I collagen and irradiated with a He+ ion beam at an energy of 150 keV with fluences of 1 × 1014 ions/cm2 (ion stent group). Ten stents had no treatment (non‐ion stent group). The self‐expanding stents were implanted into the right and left peripheral femoral arteries of 15 beagle dogs (vessel diameter approximately 3 mm) via a 6Fr catheter under fluoroscopic guidance. Heparin (100 units/kg) was administered intravenously before implantation. Following stent implantation, no antiplatelet or anticoagulant drugs were administered. The 1‐month patency rate for the non‐ion stent group was 10% (1/10), and for the ion stent group it was 80% (16/20) with no anticoagulant or antiplatelet drugs given after stent implantation (P = 0.0004 by Fisher's exact test). Ten stents remain patent after 2 years in vivo with no anticoagulant or antiplatelet drugs. These results indicate that He+ ion‐implanted collagen‐coated Ti‐Ni self‐expanding stents have excellent antithrombogenicity and biocompatibility. This ion stent is promising for coronary and cerebral stent applications.
ISSN:0160-564X
1525-1594
DOI:10.1111/j.1525-1594.2009.00747.x