A beginner's guide to NF-kappaB signaling pathways

Nuclear factor kappaB (NF-kappaB) belongs to a family of heterodimeric transcription factors that play a key role in inflammatory and stress responses as well as in tumor cell resistance to apoptosis. These effects are due to the NF-kappaB-dependent transcription of many proinflammatory and antiapop...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2004-12, Vol.1030, p.1-13
Main Authors: Delhalle, Sylvie, Blasius, Romain, Dicato, Mario, Diederich, Marc
Format: Article
Language:English
Subjects:
Animals
Humans
NF-kappa B - metabolism
Signal Transduction
Online Access:Get full text
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Summary:Nuclear factor kappaB (NF-kappaB) belongs to a family of heterodimeric transcription factors that play a key role in inflammatory and stress responses as well as in tumor cell resistance to apoptosis. These effects are due to the NF-kappaB-dependent transcription of many proinflammatory and antiapoptotic genes, whose products ensure various cell responses to environmental conditions. The signal transduction pathways leading to NF-kappaB activation are well characterized, and the different steps implicated in these pathways involve proteins that could constitute targets for NF-kappaB inhibition. Several inhibitors aiming to prevent NF-kappaB activity and thus the transcription of target genes are studied, and a few compounds seem particularly promising. We try here to summarize the advantages that can issue from various studies on NF-kappaB.
ISSN:0077-8923
1749-6632