Low HDL cholesterol levels in type I Gaucher disease do not lead to an increased risk of cardiovascular disease

Abstract Objective A low plasma high-density lipoprotein cholesterol (HDL-c) concentration is an important risk factor for the development of atherosclerotic cardiovascular disease. HDL-c levels are abnormally low in type I Gaucher disease (GD) patients. The aim of this study was to determine whethe...

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Bibliographic Details
Published in:Atherosclerosis 2009-05, Vol.204 (1), p.267-272
Main Authors: de Fost, M, Langeveld, M, Franssen, R, Hutten, B.A, Groener, J.E.M, de Groot, E, Mannens, M.M, Bikker, H, Aerts, J.M.F.G, Kastelein, J.J.P, Hollak, C.E.M
Format: Article
Language:English
Subjects:
Adult
Aged
Apolipoprotein A-I - blood
Apolipoproteins B - blood
Atherosclerosis
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Biomarkers - blood
Blood and lymphatic vessels
Blood. Blood coagulation. Reticuloendothelial system
Cardiology. Vascular system
Cardiovascular
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnostic imaging
Cardiovascular Diseases - etiology
Carotid Artery, Common - diagnostic imaging
Carotid Artery, Internal - diagnostic imaging
Case-Control Studies
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cross-Sectional Studies
Down-Regulation
Female
Gaucher disease
Gaucher Disease - blood
Gaucher Disease - complications
Gaucher Disease - diagnostic imaging
HDL cholesterol
Humans
Lipoproteins
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Risk Assessment
Risk Factors
Ultrasonography
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Summary:Abstract Objective A low plasma high-density lipoprotein cholesterol (HDL-c) concentration is an important risk factor for the development of atherosclerotic cardiovascular disease. HDL-c levels are abnormally low in type I Gaucher disease (GD) patients. The aim of this study was to determine whether GD is associated with premature atherosclerosis. Methods Lipid profiles, apolipoproteins, and carotid artery intima-media thickness (cIMT) were analyzed in 40 type I GD patients, 34 carriers and 41 control subjects. cIMT is a non-invasive validated biomarker for the status of atherosclerosis and present and future cardiovascular disease risk. Results Compared to control subjects, patients showed decreased HDL-c (1.1 ± 0.3 mmol/L) as well as mildly decreased low-density lipoprotein cholesterol (LDL-c) levels (2.8 ± 0.7 mmol/L), with an increased ApoB/ApoA1 ratio. In carriers, HDL-c levels were normal, but LDL-c levels were decreased (2.7 ± 0.8 mmol/L). Mean cIMT measurements were not different in the three study groups (patients: 0.63 ± 0.1 mm versus carriers: 0.64 ± 0.1 mm versus control subjects: 0.65 ± 0.1 mm). Conclusion In Gaucher disease low HDL-c levels do not lead to premature atherosclerosis as assessed by cIMT measurement. This indicates that the inverse relationship between levels of HDL-c and risk of cardiovascular disease in the general population may not be present in all conditions characterised by low HDL-c levels.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2008.08.027