Prognostic influence of immunohistochemically detected lymph node micrometastasis and histological subtype in pN0 oesophageal cancer

Abstract Introduction Differences in frequency and clinical impact of lymph node micrometastasis between histological subtypes of oesophageal cancer have not been determined. Methods 1204 lymph nodes from 32 squamous cell carcinomas and 54 adenocarcinomas with complete resection and pN0 status were...

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Bibliographic Details
Published in:European journal of surgical oncology 2009-06, Vol.35 (6), p.593-599
Main Authors: Zingg, U, Montani, M, Busch, M, Metzger, U, Went, P, Oertli, D
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - pathology
Esophageal Neoplasms - pathology
Female
Hematology, Oncology and Palliative Medicine
Histological subtype
Humans
Immunohistochemistry
Isolated tumour cells
Lymph node micrometastasis
Lymph Nodes - pathology
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Staging
Oesophageal cancer
Prognosis
Surgery
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Summary:Abstract Introduction Differences in frequency and clinical impact of lymph node micrometastasis between histological subtypes of oesophageal cancer have not been determined. Methods 1204 lymph nodes from 32 squamous cell carcinomas and 54 adenocarcinomas with complete resection and pN0 status were re-evaluated using a serial sectioning protocol including immunohistochemistry. Intra-nodal tumour cells were classified as micrometastases (0.2–2 mm) or isolated tumour cells (
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2008.12.001