Effect of CT screening on smoking habits at 1-year follow-up in the Danish Lung Cancer Screening Trial (DLCST)

Background:The effect of low-dose CT screening for lung cancer on smoking habits has not been reported in large randomised controlled trials.Methods:This study evaluated the effect on smoking habits of screening with low-dose CT at 1-year follow up in the Danish Lung Cancer Screening Trial (DLCST),...

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Bibliographic Details
Published in:Thorax 2009-05, Vol.64 (5), p.388-392
Main Authors: Ashraf, H, Tønnesen, P, Holst Pedersen, J, Dirksen, A, Thorsen, H, Døssing, M
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cardiology. Vascular system
Female
Forced Expiratory Volume - physiology
Humans
Lung cancer
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - psychology
Male
Mass Screening - psychology
Medical sciences
Middle Aged
Pneumology
Recurrence
Smoking - physiopathology
Smoking - psychology
Smoking Cessation - psychology
Tobacco, tobacco smoking
Tomography, X-Ray Computed
Toxicology
Tumors of the respiratory system and mediastinum
Vital Capacity - physiology
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Summary:Background:The effect of low-dose CT screening for lung cancer on smoking habits has not been reported in large randomised controlled trials.Methods:This study evaluated the effect on smoking habits of screening with low-dose CT at 1-year follow up in the Danish Lung Cancer Screening Trial (DLCST), a 5-year randomised controlled trial comprising 4104 subjects; 2052 subjects received annual low-dose CT scan (CT group) and 2052 received no intervention (control group). Participants were healthy current and former smokers (>4 weeks since smoking cessation) with a tobacco consumption of >20 pack years. Smoking habits were determined at baseline and at annual screening. Smoking status was verified using exhaled carbon monoxide levels. Lung function tests, nicotine dependency and motivation to quit smoking were assessed. Quit rates and relapse rates were determined at 1-year follow-up for all subjects.Results:At 1 year the quit rates among smokers were 11.9% in the CT group and 11.8% in the control group (p = 0.95). Relapse rates for former smokers were 10.0% and 10.5% in the CT and control groups, respectively (p = 0.81). Significant predictors (p
ISSN:0040-6376
1468-3296
DOI:10.1136/thx.2008.102475