Expression of tenascin-c and CD44 receptors in cardiac myxomas

Abstract Background Myxomas are the most frequent primary cardiac neoplasms. They have an abundant extracellular matrix rich in proteoglycans. Interactions between cells and matrix are very important in the development of tumors, but data about myxomas in this setting are scarce because of the rarit...

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Bibliographic Details
Published in:Cardiovascular pathology 2009-05, Vol.18 (3), p.173-177
Main Authors: Donato, Giuseppe, Conforti, Francesco, Zuccalà, Valeria, Russo, Emilio, Maltese, Lorenza, Perrotta, Ida, Amorosi, Andrea
Format: Article
Language:English
Subjects:
Angiogenesis
Cardiac myxoma
CD44
Extracellular matrix
Female
Heart Neoplasms - blood supply
Heart Neoplasms - chemistry
Heart Neoplasms - immunology
Heart Neoplasms - surgery
Humans
Hyaluronan Receptors - analysis
Immunohistochemistry
Male
Middle Aged
Myxoma - blood supply
Myxoma - chemistry
Myxoma - immunology
Myxoma - surgery
Neovascularization, Pathologic - immunology
Neovascularization, Pathologic - metabolism
Pathology
Tenascin - analysis
Tenascin-c
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Summary:Abstract Background Myxomas are the most frequent primary cardiac neoplasms. They have an abundant extracellular matrix rich in proteoglycans. Interactions between cells and matrix are very important in the development of tumors, but data about myxomas in this setting are scarce because of the rarity of such neoplasms. The expression of tenascin-c and hyaluran receptors in cardiac myxoma has never been investigated. Moreover, it is now well recognized that cells of cardiac myxoma differentiate along endothelial lines. Methods We have analyzed left atrial myxomas from 13 consecutive patients (six male and seven female, surgically treated), via immunohistochemical methods for the expression of molecules also implicated in angiogenesis in normal and pathological conditions, like tenascin-c and hyaluran receptors CD44s, CD44v5 and CD44v6. Results Our data suggest that tenascin-c and CD44s play a synergic and perhaps complementary role in development of cardiac myxomas. In particular, tenascin-c seems to promote aggregation of cells and differentiation in vascular structures, whereas CD44s receptors might be important for cellular motility. Cell proliferation rate in such tumors was very low (MIB-1 labeling index
ISSN:1054-8807
1879-1336
DOI:10.1016/j.carpath.2008.03.006