Nucleic Acid-Triggered Fluorescent Probe Activation by the Staudinger Reaction

Highly sequence specific and sensitive detection systems for DNA or RNA in vivo would be of great use in biology and medicine for monitoring gene expression and diagnosing diseased cells. Herein we describe a new nucleic acid-triggered fluorescent probe system that is activated by a biocompatible an...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2004-12, Vol.126 (50), p.16324-16325
Main Authors: Cai, Jianfeng, Li, Xiaoxu, Yue, Xuan, Taylor, John Stephen
Format: Article
Language:English
Subjects:
Acetates - chemistry
Amino Acids - chemistry
Biological and medical sciences
Fluorenes - chemistry
Fluoresceins - chemical synthesis
Fluoresceins - chemistry
Fluoresceins - pharmacokinetics
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fluorescent Dyes - pharmacokinetics
Fundamental and applied biological sciences. Psychology
Kinetics
Miscellaneous
Molecular biophysics
Organophosphorus Compounds - chemistry
Peptide Nucleic Acids - chemical synthesis
Peptide Nucleic Acids - chemistry
Peptide Nucleic Acids - metabolism
Physical chemistry in biology
Prodrugs - chemical synthesis
Prodrugs - chemistry
Prodrugs - pharmacokinetics
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Summary:Highly sequence specific and sensitive detection systems for DNA or RNA in vivo would be of great use in biology and medicine for monitoring gene expression and diagnosing diseased cells. Herein we describe a new nucleic acid-triggered fluorescent probe system that is activated by a biocompatible and chemoselective Staudinger reaction.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja0452626