A review of the lung transplantation programme in Ireland 2005–2007

Objective: Lung transplantation is a recognised surgical option for patients with end stage respiratory disease. We present data relating to the initiation of the Irish lung transplant programme in 2005. Methods: Seventeen patients: 7 male and 10 female have undergone lung transplantation. The indic...

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Bibliographic Details
Published in:European journal of cardio-thoracic surgery 2009-05, Vol.35 (5), p.807-811
Main Authors: Bartosik, Waldemar, Egan, Jim J., Soo, Alan, Remund, Kaspar F., Nölke, Lars, McCarthy, James F., Wood, Alfred E.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antibiotic Prophylaxis - methods
Biological and medical sciences
Cardiology. Vascular system
End stage respiratory disease
Female
Graft Rejection
Humans
Immunosuppression
Immunosuppression - methods
Ireland
Lung Diseases - surgery
Lung transplantation
Lung Transplantation - adverse effects
Lung Transplantation - methods
Lung Transplantation - standards
Male
Medical sciences
Middle Aged
Pneumology
Primary Graft Dysfunction - etiology
Program Evaluation
Retrospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Survival Analysis
Treatment Outcome
Young Adult
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Summary:Objective: Lung transplantation is a recognised surgical option for patients with end stage respiratory disease. We present data relating to the initiation of the Irish lung transplant programme in 2005. Methods: Seventeen patients: 7 male and 10 female have undergone lung transplantation. The indications for lung transplantation included COPD (n = 8), idiopathic pulmonary fibrosis (n = 5), bronchiolitis obliterans (n = 2), lymphangioleiomyomatosis (n = 1), and cystic fibrosis (n = 1). Eleven single lungs transplants were completed, while six patients underwent double sequential lung transplantation. The immunosuppression regimen included basiliximab as induction therapy, with steroids, mycophenolate mofetil nd cyclosporine or tacrolimus. Results: The operative mortality was zero. One patient died at 10 months post double lung transplantation secondary to bronchiolitis obliterans. Primary graft dysfunction was observed in two patients who required ventilatory support for 3 and 5 days respectively. Acute cellular rejection was observed in four patients (grade A2 n = 3, grade A3 n = 2). The cumulative 1-year survival was 94.1%, which compares favourably to an international standard of 78%. Conclusions: The initiation of a lung transplant programme in Ireland has been successfully undertaken and initially provided results comparable to established lung transplant programs.
ISSN:1010-7940
1873-734X
DOI:10.1016/j.ejcts.2008.10.055