Anhedonia and activity deficits in rats: impact of post-stroke depression

Abstract Animal models may allow investigation into the aetiology and treatment of various human disorders. In the present study, a rat model for post-stroke depression (PSD) has been developed using middle cerebral artery occlusion (MCAO), followed by an 18-day chronic mild stress (CMS) paradigm in...

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Bibliographic Details
Published in:Journal of psychopharmacology (Oxford) 2009-05, Vol.23 (3), p.295-304
Main Authors: Wang, SH, Zhang, ZJ, Guo, YJ, Zhou, H, Teng, GJ, Chen, BA
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Animal models
Animals
Antidepressive Agents, Second-Generation - pharmacology
Behavior, Animal - drug effects
Biological and medical sciences
Brain
Cerebral blood flow
Citalopram
Citalopram - pharmacology
Depression
Depression - drug therapy
Depression - etiology
Depression - physiopathology
Disease Models, Animal
Hedonic response
Ischemia
Isolation
Male
Medical sciences
Mental depression
Middle Cerebral Artery
Mood disorders
Motor Activity - drug effects
Neurology
Neuropharmacology
Occlusion
Open-field behavior
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
Rats
Rats, Sprague-Dawley
Reinforcement
Reproducibility
Reward
Rodents
Social Isolation
Stress, Psychological - physiopathology
Stroke
Stroke - complications
Sucrose
Sucrose - administration & dosage
Sugar
Vascular diseases and vascular malformations of the nervous system
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Summary:Abstract Animal models may allow investigation into the aetiology and treatment of various human disorders. In the present study, a rat model for post-stroke depression (PSD) has been developed using middle cerebral artery occlusion (MCAO), followed by an 18-day chronic mild stress (CMS) paradigm in conjuncture with isolation rearing. The open-field test (OFT) and the sucrose consumption test were used to assess depression-like behaviour and the effects of the antidepressant citalopram. CMS induced behavioural changes in the ischemic animals, including decreased locomotor and rearing activity and reduced sucrose preference (compared with baseline, control and stroke groups respectively), all these behaviours were reversed by chronic administration of citalopram. During the recovery period for the PSD models, the open-field activity and preference for sweet sucrose solution decreased continually, opposed to rats subjected to stress only. Decreased locomotor and rearing represents activity deficits, whereas reduced sucrose preference may indicate desensitisation of the brain reward mechanism (anhedonia). Our findings suggest that anhedonia, one of the core symptoms in patients with PSD, and activity deficits can be found in the MCAO+CMS group of animals. Furthermore, citalopram can ameliorate the behavioural abnormalities observed in these animals. With high validity, good operability and repeatability, our findings suggest that the ischemic rat CMS model is an appropriate model for further PSD research.
ISSN:0269-8811
1461-7285
DOI:10.1177/0269881108089814