Infiltration of Macrophages Through the Atrial Endocardium of Inflammation-Induced Rats: Contribution of Fractalkine

Background: Inflammatory processes in the atria during systemic inflammation remain unclear, so this study tested the hypothesis that macrophages infiltrate the atrial myocardium mainly through the atrial endocardium with the contribution of fractalkine. Methods and Results: Sprague-Dawley rats were...

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Bibliographic Details
Published in:Circulation Journal 2009, Vol.73(5), pp.932-937
Main Authors: Date, Taro, Yamashita, Takeshi, Sekiguchi, Akiko, Iwasaki, Yu-ki, Aizawa, Tadanori, Yamane, Teiichi, Aramaki, Yasuko, Komukai, Kimiaki, Taniguchi, Ikuo, Yoshimura, Michihiro
Format: Article
Language:English
Subjects:
Animals
Antibodies - administration & dosage
Atrium
Chemokine CX3CL1 - metabolism
Chemokines
Chemotaxis
Disease Models, Animal
Endocardium
Endocardium - immunology
Heart Atria - immunology
Inflammation
Inflammation - chemically induced
Inflammation - immunology
Injections, Intraperitoneal
Lipopolysaccharides
Macrophages - immunology
Male
Rats
Rats, Sprague-Dawley
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Summary:Background: Inflammatory processes in the atria during systemic inflammation remain unclear, so this study tested the hypothesis that macrophages infiltrate the atrial myocardium mainly through the atrial endocardium with the contribution of fractalkine. Methods and Results: Sprague-Dawley rats were injected with lipopolysaccharide (LPS) to simulate inflammation in the atria. Inflammation was immunohistologically assessed by the presence of macrophages. Macrophage infiltration was diffuse throughout the atrial myocardium after LPS injection. At an earlier phase after LPS injection, the number of macrophages dramatically increased, mainly in the atrial endocardium, and the expression of fractalkine protein was markedly increased by treatment with LPS in the atrial endocardium. The LPS-induced increase in atrial macrophage infiltration was significantly suppressed by neutralizing the fractalkine protein (P
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-08-0856