Bidirectional Metalation of Hydrobenzoin: Direct Access to New Chiral Ligands and Auxiliaries

A bidirectional ortho metalation of the readily available chiral diol hydrobenzoin has been developed that provides direct access to new ortho-functionalized hydrobenzoin derivatives. This one-pot procedure should broaden the utility of hydrobenzoin as an auxiliary and ligand in asymmetric synthesis...

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Bibliographic Details
Published in:Organic letters 2009-05, Vol.11 (9), p.1903-1906
Main Authors: Cho, Inhee, Meimetis, Labros, Britton, Robert
Format: Article
Language:English
Subjects:
Benzoin - analogs & derivatives
Benzoin - chemical synthesis
Benzoin - chemistry
Catalysis
Ligands
Molecular Structure
Stereoisomerism
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Summary:A bidirectional ortho metalation of the readily available chiral diol hydrobenzoin has been developed that provides direct access to new ortho-functionalized hydrobenzoin derivatives. This one-pot procedure should broaden the utility of hydrobenzoin as an auxiliary and ligand in asymmetric synthesis.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol900323u