Suppression of Tumor Growth by Palm Tocotrienols Via the Attenuation of Angiogenesis

Previous studies have revealed that tocotrienol-rich fractions (TRF) from palm oil inhibit the proliferation and the growth of solid tumors. The anticancer activity of TRF is said to be caused by several mechanisms, one of which is antiangiogenesis. In this study, we looked at the antiangiogenic eff...

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Bibliographic Details
Published in:Nutrition and cancer 2009-05, Vol.61 (3), p.367-373
Main Authors: Weng-Yew, Wong, Selvaduray, Kanga Rani, Ming, Cheng Hwee, Nesaretnam, Kalanithi
Format: Article
Language:English
Subjects:
angiogenesis
angiogenesis growth factor
Angiogenesis Inhibitors - pharmacology
Animals
anticarcinogenic activity
Anticarcinogenic Agents - pharmacology
Biological and medical sciences
Cell Line, Tumor
Cell Movement - drug effects
Cell Proliferation - drug effects
Chickens
chorioallantoic membrane
Chorioallantoic Membrane - drug effects
endothelial cells
Endothelial Cells - drug effects
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
human cell lines
Humans
in vitro studies
Mice
Mice, Inbred BALB C
neoplasms
Palm Oil
palm oils
Plant Oils - chemistry
tocotrienols
Tocotrienols - pharmacology
umbilical veins
Vascular Endothelial Growth Factor A - antagonists & inhibitors
Vascular Endothelial Growth Factor A - blood
vascular endothelial growth factors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Previous studies have revealed that tocotrienol-rich fractions (TRF) from palm oil inhibit the proliferation and the growth of solid tumors. The anticancer activity of TRF is said to be caused by several mechanisms, one of which is antiangiogenesis. In this study, we looked at the antiangiogenic effects of TRF. In vitro investigations of the antiangiogenic activities of TRF, δ-tocotrienol (δT3), and α-tocopherol ((α)Toc) were carried out in human umbilical vein endothelial cells (HUVEC). TRF and δT3 significantly inhibited cell proliferation from 4 μg/ml onward (P < 0.05). Cell migration was inhibited the most by δT3 at 12 μg/ml. Anti-angiogenic properties of TRF were carried out further in vivo using the chick embryo chorioallantoic membrane (CAM) assay and BALB/c mice model. TRF at 200 μg/ml reduced the vascular network on CAM. TRF treatment of 1 mg/mouse significantly reduced 4T1 tumor volume in BALB/c mice. TRF significantly reduced serum vascular endothelial growth factor (VEGF) level in BALB/c mice. In conclusion, this study showed that palm tocotrienols exhibit anti-angiogenic properties that may assist in tumor regression.
ISSN:0163-5581
1532-7914
DOI:10.1080/01635580802582736