Re-expression of Locomotor Function After Partial Spinal Cord Injury

S. Rossignol 1 ,2 , G. Barrière 1 ,2 , O. Alluin 1 ,2 and A. Frigon 1 1 Department of Physiology, Groupe de Recherche sur le Système Nerveux Central, Faculty of Medicine, Université de Montréal, Montreal, Canada; and 2 Multidisciplinary Team in Locomotor Rehabilitation after Spinal Cord Injury, Cana...

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Published in:Physiology (Bethesda, Md.) Md.), 2009-04, Vol.24 (2), p.127-139
Main Authors: Rossignol, S, Barriere, G, Alluin, O, Frigon, A
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Animals
Cats
Disease Models, Animal
Humans
Instinct
Locomotion - physiology
Mice
Nerve Regeneration - physiology
Neural Pathways - physiology
Rats
Spinal Cord Injuries - physiopathology
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Summary:S. Rossignol 1 ,2 , G. Barrière 1 ,2 , O. Alluin 1 ,2 and A. Frigon 1 1 Department of Physiology, Groupe de Recherche sur le Système Nerveux Central, Faculty of Medicine, Université de Montréal, Montreal, Canada; and 2 Multidisciplinary Team in Locomotor Rehabilitation after Spinal Cord Injury, Canadian Institutes of Health Research (CIHR) serge.rossignol{at}umontreal.ca After a complete spinal section, quadruped mammals (cats, rats, and mice) can generally regain hindlimb locomotion on a treadmill because the spinal cord below the lesion can express locomotion through a neural circuitry termed the central pattern generator (CPG). In this review, we propose that the spinal CPG also plays a crucial role in the locomotor recovery after incomplete spinal cord injury.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00042.2008