Maternal undernutrition programmes atherosclerosis in the ApoE3-Leiden mouse

Poor quality of nutrition during fetal development is associated with adverse health outcomes in adult life. Epidemiological studies suggest that markers of fetal undernutrition are predictive of risk of the metabolic syndrome and CHD. Here we show that feeding a low-protein diet during pregnancy pr...

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Bibliographic Details
Published in:British journal of nutrition 2009-04, Vol.101 (8), p.1185-1194
Main Authors: Yates, Zoe, Tarling, Elizabeth J., Langley-Evans, Simon C., Salter, Andrew M.
Format: Article
Language:English
Subjects:
animal models
Animals
aortic arch
Apolipoprotein E3 - genetics
Atherosclerosis
Atherosclerosis - embryology
Atherosclerosis - physiopathology
binding proteins
Biological and medical sciences
Cholesterol
Cholesterol - blood
Developing countries
Diet
Diet, Protein-Restricted
Dietary Proteins - administration & dosage
Feeding. Feeding behavior
Female
Females
fetal development
Fetal Development - physiology
Fundamental and applied biological sciences. Psychology
Gene expression
Genotype
Genotype & phenotype
heart
heart diseases
hepatic sterol regulatory element-binding protein-1C
hyperlipidemia
LDCs
lesions (animal)
Lipid metabolism
Lipid Metabolism - physiology
low protein diet
Male
malnutrition
maternal nutrition
messenger RNA
Metabolic syndrome
Metabolism and Metabolic Studies
Metabolites
Mice
Mice, Inbred C57BL
Mice, Transgenic
Nutrition
Oligonucleotide Array Sequence Analysis - methods
Plasma
Pregnancy
Prenatal Exposure Delayed Effects - physiopathology
Prenatal Nutritional Physiological Phenomena
Programming
Protein restriction
Proteins
Transgenic animals
Triglycerides - blood
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Weaning
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Summary:Poor quality of nutrition during fetal development is associated with adverse health outcomes in adult life. Epidemiological studies suggest that markers of fetal undernutrition are predictive of risk of the metabolic syndrome and CHD. Here we show that feeding a low-protein diet during pregnancy programmed the development of atherosclerosis in ApoE*3-Leiden mice. ApoE*3-Leiden mice carry a mutation of human ApoE*3 rendering them prone to atherosclerosis when fed a diet rich in cholesterol. It was noted that fetal exposure to protein restriction led to a greater degree of dyslipidaemia in mice when fed an atherogenic diet, with low-protein-exposed ApoE*3 mice having elevated total plasma cholesterol (34 % higher; P 
ISSN:0007-1145
1475-2662
DOI:10.1017/S0007114508066786