Arterial Stiffness and Wave Reflections in Patients With Sickle Cell Disease

We tested the hypothesis that lower blood pressure and increased vasodilatation reported in sickle cell disease (SCD) patients with hemoglobin SS genotype (SS) are translated by lower arterial stiffness determined by pulse wave velocity (PWV) and wave reflections assessed by augmentation index (AI)....

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2004-12, Vol.44 (6), p.924-929
Main Authors: Lemogoum, Daniel, Van Bortel, Luc, Najem, Boutaina, Dzudie, Anasthase, Teutcha, Charles, Madu, Ernest, Leeman, Marc, Degaute, Jean-Paul, van de Borne, Philippe
Format: Article
Language:English
Subjects:
Adult
Anemia, Sickle Cell - physiopathology
Antihypertensive agents
Arteries - physiology
Biological and medical sciences
Blood Flow Velocity
Blood Pressure - physiology
Blood vessels and receptors
Cardiovascular system
Female
Fundamental and applied biological sciences. Psychology
Heart Rate
Hemoglobin A
Hemoglobin, Sickle
Humans
Male
Medical sciences
Pharmacology. Drug treatments
Regression Analysis
Vasodilation - physiology
Vertebrates: cardiovascular system
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Summary:We tested the hypothesis that lower blood pressure and increased vasodilatation reported in sickle cell disease (SCD) patients with hemoglobin SS genotype (SS) are translated by lower arterial stiffness determined by pulse wave velocity (PWV) and wave reflections assessed by augmentation index (AI). We enrolled 20 SS (8 females; 12 male) patients closely matched for age, gender, height, and body mass index to 20 subjects with hemoglobin AA genotype (AA). Carotid–femoral PWV (PWVCF) and carotid–radial PWV (PWVCR) were recorded with the Complior device. Aortic AI was derived from pressure wave analysis (SphygmocoR). PWVCF and PWVCR were lower in SS than in AA (4.5±0.7 m/s versus 6.9±0.9 m/s, P
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.0000148506.73622.ba