Pilot study on the effect of estrogen replacement therapy on brain dopamine transporter availability in healthy, postmenopausal women

Authors investigated the association between estrogen replacement therapy (ERT) and dopamine transporter (DAT) availability in women. Thirteen postmenopausal women were administered ERT and underwent neuroimaging, using single-photon emission computed tomography (SPECT) and [99mTc]TRODAT-1, a radiol...

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Bibliographic Details
Published in:The American journal of geriatric psychiatry 2004-11, Vol.12 (6), p.621-630
Main Authors: Gardiner, Sara A, Morrison, Mary F, Mozley, P David, Mozley, Lyn Harper, Brensinger, Colleen, Bilker, Warren, Newberg, Andrew, Battistini, Michelle
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Brain - diagnostic imaging
Brain - drug effects
Dominance, Cerebral - physiology
Dopamine Plasma Membrane Transport Proteins
Estrogen Replacement Therapy
Estrogens, Conjugated (USP) - administration & dosage
Female
Humans
Medroxyprogesterone Acetate - administration & dosage
Membrane Glycoproteins - metabolism
Membrane Transport Proteins - metabolism
Middle Aged
Nerve Tissue Proteins - metabolism
Organotechnetium Compounds - pharmacokinetics
Postmenopause
Putamen - diagnostic imaging
Putamen - drug effects
Reference Values
Tomography, Emission-Computed, Single-Photon
Tropanes - pharmacokinetics
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Summary:Authors investigated the association between estrogen replacement therapy (ERT) and dopamine transporter (DAT) availability in women. Thirteen postmenopausal women were administered ERT and underwent neuroimaging, using single-photon emission computed tomography (SPECT) and [99mTc]TRODAT-1, a radioligand that binds DAT. In this 6-week pilot study, subjects underwent SPECT before ERT, after 4 weeks of 0.625 mg/day of conjugated estrogens (CEE), and after an additional 2 weeks of 0.625 mg/day CEE plus 10 mg/day of medroxyprogesterone acetate. Specific uptake values (SUVs) of [99mTc]TRODAT-1 were calculated for the caudate and putamen. When compared with baseline values, [99mTc]TRODAT-1 binding demonstrated a modest, but statistically significant, increase in the left anterior putamen after 4 weeks of CEE. After the 6-week ERT intervention, both the left and right anterior putamen demonstrated an increase in SUVs. Short-term administration of ERT in postmenopausal women is associated with a modest increase in DAT in the putamen. These findings may further the understanding of how ERT is associated with improvement in Parkinson's disease and late-onset schizophrenia.
ISSN:1064-7481
1545-7214
DOI:10.1097/00019442-200411000-00008