Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell

Rhizoma drynariae is used commonly in the treatment of osteoporosis and bone nonunion in traditional Chinese medicine. Modern pharmacological research indicates that naringin is the main effective component of rhizoma drynariae, which can induce the expression of the osteogenic marker in the osteobl...

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Bibliographic Details
Published in:European journal of pharmacology 2009-04, Vol.607 (1), p.1-5
Main Authors: Peng-Zhang, Dai, Ke-rong, Yan, Shi-gui, Yan, Wei-qi, Chao-Zhang, Chen, De-qiang, Bo-Xu, Xu, Zhan-wang
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers - metabolism
Bone
Cell Differentiation - drug effects
Cell Proliferation - drug effects
Cells, Cultured
Differentiation
Dose-Response Relationship, Drug
Flavanones - administration & dosage
Flavanones - isolation & purification
Flavanones - pharmacology
Herbs
Human bone mesenchymal stem cell
Humans
Medical sciences
Medicine, Chinese Traditional
Mesenchymal Stem Cells - drug effects
Mesenchymal Stem Cells - metabolism
Mesenchyme
Naringin
Nonunion
Osteoblasts
Osteogenesis - drug effects
Osteogenic differentiation
Osteoporosis
Pharmacology. Drug treatments
Polypodiaceae - chemistry
Rhizoma drynariae
Stem cells
Traditional Chinese Medicine
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Summary:Rhizoma drynariae is used commonly in the treatment of osteoporosis and bone nonunion in traditional Chinese medicine. Modern pharmacological research indicates that naringin is the main effective component of rhizoma drynariae, which can induce the expression of the osteogenic marker in the osteoblast cell line. However, no former study has described its effect on bone mesenchymal stem cells (BMSCs). In our experiment, we co-cultured human BMSCs with different concentrations of naringin solution, then the osteogenic differentiation markers and proliferation ability were analyzed. The results indicated that a certain concentration (1–100 μg/ml) of the naringin solution may enhance the proliferation and osteogenic differentiation of human BMSCs. Also, our research explains excellently the anti-osteoporotic and bone nonunion treatment mechanism of rhizoma drynariae, thus contributing to the exploration of osteogenic differentiation agents from Chinese herbs.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2009.01.035