Inflammatory Activation and Left Ventricular Mass in Essential Hypertension

Background Inflammation is an independent risk factor for high blood pressure, and as a consequence inflammatory cytokines could be related with left ventricular hypertrophy (LVH). We sought to assess the association and predictive role of different cytokine levels with LVH in a group of patients wi...

Full description

Saved in:
Bibliographic Details
Published in:American journal of hypertension 2009-04, Vol.22 (4), p.444-450
Main Authors: Roselló-Lletí, Esther, Rivera, Miguel, Martínez-Dolz, Luís, González Juanatey, Jose R., Cortés, Raquel, Jordán, Alejandro, Morillas, Pedro, Lauwers, Catheline, Calabuig, Jose R., Antorrena, Isabel, de Rivas, Beatriz, Portolés, Manuel, Bertomeu, Vicente
Format: Article
Language:English
Subjects:
Adult
Aged
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Cross-Sectional Studies
Etanercept
Female
Humans
Hypertension - complications
Hypertension - pathology
Hypertrophy, Left Ventricular - complications
Hypertrophy, Left Ventricular - pathology
Immunoglobulin G - blood
Inflammation - complications
Inflammation - physiopathology
Interleukin 1 Receptor Antagonist Protein - blood
Interleukin-6 - blood
Male
Medical sciences
Middle Aged
Receptors, Tumor Necrosis Factor - blood
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Inflammation is an independent risk factor for high blood pressure, and as a consequence inflammatory cytokines could be related with left ventricular hypertrophy (LVH). We sought to assess the association and predictive role of different cytokine levels with LVH in a group of patients with essential hypertension (HT). Methods We studied 251 asymptomatic hypertensive patients (142 with LVH and 109 without LVH), referred from 11 hospitals. A routine physical examination, laboratory analyses, and echo-Doppler study were performed. Plasma soluble tumor necrosis factor (TNF) receptors (sTNF-R1 and sTNF-R2), interleukin-6 (IL-6), and interleukin-1 receptor antagonist (IL-1ra) were centrally determined. Results Hypertensive patients with LVH had higher inflammatory cytokine levels than the group without hypertrophy (P < 0.001). Multivariate linear regression reported that sTNF-R1 (P < 0.01) was an independent predictor of left ventricular mass index (LVMI). All cytokines had significant area under the curves for detection of LVH, but sTNF-R1 has the highest area, 0.71 ± 0.03 (P < 0.001). Finally, prevalence of LVH was increased in the group of patients with higher cytokine levels, and logistic regression analysis showed that sTNF-R1 (odds ratio = 2.59, 95% CI of 1.14–5.87) was an independent predictor of LVH. Conclusions Cytokine levels were significantly correlated with LVMI in hypertensive patients. The sTNF-R1 was an independent predictor of LVMI. Plasma sTNF-R1 concentrations could be a predictive factor of LVH in patients with essential HT.
ISSN:0895-7061
1879-1905
1941-7225
DOI:10.1038/ajh.2008.369