Prevalence of HPV infection by cervical cytologic status in Brazil

Abstract Objectives To assess the prevalence of human papillomavirus (HPV) infection according to cervical cytologic status in northeastern Brazil; identify other risk factors for low- and high-grade squamous intraepithelial lesions (LSILs and HSILs); and identify the most prevalent HPV genotypes as...

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Bibliographic Details
Published in:International journal of gynecology and obstetrics 2009-04, Vol.105 (1), p.21-24
Main Authors: Fernandes, José Veríssimo, de Vasconcellos Meissner, Rosely, de Carvalho, Maria Goretti Freire, de Medeiros Fernandes, Thales Allyrio Araújo, de Azevedo, Paulo Roberto Medeiros, Villa, Luisa Lina
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Biological and medical sciences
Brazil - epidemiology
Cervical Intraepithelial Neoplasia - epidemiology
Cervical Intraepithelial Neoplasia - pathology
Cervical Intraepithelial Neoplasia - virology
Cervical lesions
Cervix Uteri - cytology
Cervix Uteri - virology
Female
Genotype
Gynecology. Andrology. Obstetrics
Human papillomavirus
Human papillomavirus 16 - isolation & purification
Humans
Immunoblotting
Medical sciences
Middle Aged
Obstetrics and Gynecology
Papillomaviridae - genetics
Papillomaviridae - isolation & purification
Papillomavirus Infections - epidemiology
Papillomavirus Infections - pathology
Papillomavirus Infections - virology
Polymerase Chain Reaction
Prevalence
Risk Factors
Sexual Partners
Smoking - adverse effects
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - virology
Vaginal Smears
Young Adult
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Summary:Abstract Objectives To assess the prevalence of human papillomavirus (HPV) infection according to cervical cytologic status in northeastern Brazil; identify other risk factors for low- and high-grade squamous intraepithelial lesions (LSILs and HSILs); and identify the most prevalent HPV genotypes associated with the lesions. Method Two cervical smears were collected from 250 women referred for cancer screening, one for cytologic examination and the other to test for the presence of HPV by PCR with genotyping by dot blot hybridization. Result There were 110 healthy cervices, 82 LSILs, and 58 HSILs. The overall HPV prevalence was 48%, with higher rates for HSILs, and HPV-16 was the most prevalent type. Age, multiple sexual partners, type of HPV present, smoking, and early onset of sexual activity were risk factors for cervical lesions. Conclusion Age, multiple sexual partners, and infection with HPV-16 increased the risk of having LSILs or HSILs. Early onset of sexual activity and smoking only increased the risk of having HSILs.
ISSN:0020-7292
1879-3479
DOI:10.1016/j.ijgo.2008.12.004