Anti-Müllerian hormone-based approach to controlled ovarian stimulation for assisted conception

BACKGROUND Individualization of controlled ovarian stimulation (COS) for assisted conception is complicated by variable ovarian response to follicle stimulating hormone. We hypothesized that anti-Müllerian hormone (AMH), a predictor of oocyte yield, may facilitate treatment strategies for women unde...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2009-04, Vol.24 (4), p.867-875
Main Authors: Nelson, Scott M., Yates, Robin W., Lyall, Helen, Jamieson, Maybeth, Traynor, Isabel, Gaudoin, Marco, Mitchell, Paul, Ambrose, Pat, Fleming, Richard
Format: Article
Language:English
Subjects:
Adult
Anti-Mullerian Hormone - blood
anti-Müllerian hormone
Biological and medical sciences
Clinical Protocols
Cohort Studies
Female
Follicle Stimulating Hormone - administration & dosage
GNRH AG/ANTAG
Gonadotropin-Releasing Hormone - agonists
Gonadotropin-Releasing Hormone - antagonists & inhibitors
Gynecology. Andrology. Obstetrics
Humans
Infant, Newborn
Medical sciences
ovarian stimulation
Ovulation Induction - methods
Pregnancy
Pregnancy Outcome
Prospective Studies
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Summary:BACKGROUND Individualization of controlled ovarian stimulation (COS) for assisted conception is complicated by variable ovarian response to follicle stimulating hormone. We hypothesized that anti-Müllerian hormone (AMH), a predictor of oocyte yield, may facilitate treatment strategies for women undergoing COS, to optimize safety and clinical pregnancy rates. METHODS Prospective cohort study of 538 patients in two centres with differential COS strategies based on a centralized AMH measurement. RESULTS AMH was associated with oocyte yield after ovarian stimulation in both centres, and a ‘reduced’ AMH (1 to
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/den480