Polymorphisms in equine immune response genes and their associations with infections

Polymorphic markers identified in the horse genes encoding the interleukin 12 p40 subunit, interferon gamma, tumor necrosis factor receptor 1, and inducible nitric oxide synthase were identified and tested, along with additional markers, for associations with two important horse infections: Rhodococ...

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Bibliographic Details
Published in:Mammalian genome 2004-10, Vol.15 (10), p.843-850
Main Authors: Horín, Petr, Smola, Jirrí, Matiasovic, Ján, Vyskocil, Mirko, Lukeszová, Ludmila, Tomanová, Katarína, Králík, Petr, Glasnák, Vladimír, Schröffelová, Dana, Knoll, Ales, Sedlinská, Markéta, Krenková, Leona, Jahn, Petr
Format: Article
Language:English
Subjects:
Animals
Chromosomes, Mammalian - genetics
Genes, MHC Class II - genetics
Genes, MHC Class II - immunology
Genetic Predisposition to Disease
Horses - genetics
Horses - immunology
Horses - microbiology
Interferon-gamma - genetics
Interferon-gamma - immunology
Interleukin-12 - genetics
Interleukin-12 - immunology
Lawsonia Bacteria - metabolism
Lawsonia intracellularis
Nitric oxide
Nitric Oxide Synthase - genetics
Nitric Oxide Synthase - immunology
Nitric Oxide Synthase Type II
Polymorphism, Genetic
Rhodococcus equi
Rhodococcus equi - metabolism
Tumor Necrosis Factor-alpha - genetics
Tumor Necrosis Factor-alpha - immunology
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Summary:Polymorphic markers identified in the horse genes encoding the interleukin 12 p40 subunit, interferon gamma, tumor necrosis factor receptor 1, and inducible nitric oxide synthase were identified and tested, along with additional markers, for associations with two important horse infections: Rhodococcus equi and Lawsonia intracellularis. Eight immune response-related and 14 microsatellite loci covering 12 out of 31 equine autosomes were used for the association analysis. Markers located on horse Chromosomes Eca10 and 15 were significantly associated with the presence of high numbers of R. equi in transtracheal aspirates. Significant associations of markers located on Eca9, 15, and 21 with fecal shedding of Lawsonia intracellularis were found. Marginal associations with tumor necrosis factor alpha, interferon gamma, and other genes suggested that variations in immune response-related genes could underlie the phenotypic variation observed.
ISSN:0938-8990
1432-1777
DOI:10.1007/s00335-004-2356-6