Quantification of (R)-[11C]PK11195 binding in rheumatoid arthritis

Purpose Rheumatoid arthritis (RA) involves migration of macrophages into inflamed areas. ( R )-[ 11 C]PK11195 binds to peripheral benzodiazepine receptors, expressed on macrophages, and may be used to quantify inflammation using positron emission tomography (PET). This study evaluated methods for th...

Full description

Saved in:
Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2009-04, Vol.36 (4), p.624-631
Main Authors: Kropholler, M. A., Boellaard, R., Elzinga, E. H., van der Laken, C. J., Maruyama, K., Kloet, R. W., Voskuyl, A. E., Dijkmans, B. A. C., Lammertsma, A. A.
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Agents - pharmacology
Arthritis, Rheumatoid - diagnosis
Carbon Radioisotopes - pharmacology
Cardiology
Female
Humans
Image Processing, Computer-Assisted
Imaging
Isoquinolines - pharmacology
Kinetics
Knee
Knee Joint - diagnostic imaging
Macrophages - metabolism
Male
Medical imaging
Medicine
Medicine & Public Health
Middle Aged
Nuclear Medicine
Oncology
Original Article
Orthopedics
Pharmaceuticals
Positron-Emission Tomography - methods
Radiology
Receptors, GABA-A - metabolism
Rheumatoid arthritis
Tomography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Rheumatoid arthritis (RA) involves migration of macrophages into inflamed areas. ( R )-[ 11 C]PK11195 binds to peripheral benzodiazepine receptors, expressed on macrophages, and may be used to quantify inflammation using positron emission tomography (PET). This study evaluated methods for the quantification of ( R )-[ 11 C]PK11195 binding in the knee joints of RA patients. Methods Data from six patients with RA were analysed. Dynamic PET scans were acquired in 3-D mode following ( R )-[ 11 C]PK11195 injection. During scanning arterial radioactivity concentrations were measured to determine the plasma ( R )-[ 11 C]PK11195 concentrations. Data were analysed using irreversible and reversible one-tissue and two-tissue compartment models and input functions with various types of metabolite correction. Model preferences according to the Akaike information criterion (AIC) and correlations between measures were evaluated. Correlations between distribution volume (V d ) and standardized uptake values (SUV) were evaluated. Results AIC indicated optimal performance for a one-tissue reversible compartment model including blood volume. High correlations were observed between V d obtained using different input functions ( R 2 =0.80–1.00) and between V d obtained with one- and two-tissue reversible compartment models ( R 2 =0.75–0.94). A high correlation was observed between optimal V d and SUV after injection ( R 2 =0.73). Conclusion ( R )-[ 11 C]PK11195 kinetics in the knee were best described by a reversible single-tissue compartment model including blood volume. Applying metabolite corrections did not increase sensitivity. Due to the high correlation with V d , SUV is a practical alternative for clinical use.
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-008-0987-7