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Levonorgestrel-releasing intrauterine system vs. endometrial thermal ablation for menorrhagia
OBJECTIVE: To evaluate the efficacy of a Levonorgestrel-releasing Intrauterine System (LNG-IUS) in controlling menorrhagia in comparison with endometrial thermal rollerball ablation. DESIGN: Seventy-nine consecutive patients with menorrhagia underwent either LNG-IUS insertion (n=42) or hysteroscopic...
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| Published in: | Hormones (Athens, Greece) Greece), 2009-01, Vol.8 (1), p.60-64 |
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| container_end_page | 64 |
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| container_title | Hormones (Athens, Greece) |
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| creator | Theodoridis, Theodoros D. Zepiridis, Leonidas Zafrakas, Menelaos Grimbizis, Grigoris Tantsis, Antonios Kyrou, Dimitra Bontis, John N. |
| description | OBJECTIVE: To evaluate the efficacy of a Levonorgestrel-releasing Intrauterine System (LNG-IUS) in controlling menorrhagia in comparison with endometrial thermal rollerball ablation. DESIGN: Seventy-nine consecutive patients with menorrhagia underwent either LNG-IUS insertion (n=42) or hysteroscopical endometrial thermal rollerball ablation (n=37) in a prospective, observational, comparative study. Women reported duration of uterine bleeding in days prior to, and six and 12 months after each intervention. Prior to each intervention, endometrial, cervical or other pathological conditions of the genital tract were excluded. GnRH analogues for endometrial suppression were given for ten weeks before endometrial ablation but not prior to LNG-IUS insertion. RESULTS: There were no differences in duration of uterine bleeding before each intervention in the two groups. The duration of uterine bleeding was lower in the LNG-IUS group as compared with endometrial ablation at six (p |
| doi_str_mv | 10.14310/horm.2002.1223 |
| format | article |
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DESIGN: Seventy-nine consecutive patients with menorrhagia underwent either LNG-IUS insertion (n=42) or hysteroscopical endometrial thermal rollerball ablation (n=37) in a prospective, observational, comparative study. Women reported duration of uterine bleeding in days prior to, and six and 12 months after each intervention. Prior to each intervention, endometrial, cervical or other pathological conditions of the genital tract were excluded. GnRH analogues for endometrial suppression were given for ten weeks before endometrial ablation but not prior to LNG-IUS insertion. RESULTS: There were no differences in duration of uterine bleeding before each intervention in the two groups. The duration of uterine bleeding was lower in the LNG-IUS group as compared with endometrial ablation at six (p<0.001) and 12 months (p<0.001) after each intervention. Furthermore, the effect on reduction of bleeding was stronger in the LNG-IUS group as compared with the endometrial ablation group at six (p<0.001) and 12 months (p<0.001). CONCLUSIONS: The LNG-IUS was more efficacious than endometrial thermal ablation in reducing duration of uterine bleeding at six and 12 months post-intervention.</description><identifier>ISSN: 1109-3099</identifier><identifier>EISSN: 2520-8721</identifier><identifier>DOI: 10.14310/horm.2002.1223</identifier><identifier>PMID: 19269922</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Endocrinology ; Endometrial Ablation Techniques - economics ; Female ; Humans ; Intrauterine Devices, Medicated - economics ; Levonorgestrel - administration & dosage ; Levonorgestrel - therapeutic use ; Medicine ; Medicine & Public Health ; Menorrhagia - drug therapy ; Metabolic Diseases ; Prospective Studies ; Research Paper ; Uterine Hemorrhage - drug therapy ; Young Adult</subject><ispartof>Hormones (Athens, Greece), 2009-01, Vol.8 (1), p.60-64</ispartof><rights>Hellenic Endocrine Society 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-83716060b1cf133461d1c8e7cd5c448bc69082f3fed4ab741c9a703b2d4c46d63</citedby><cites>FETCH-LOGICAL-c377t-83716060b1cf133461d1c8e7cd5c448bc69082f3fed4ab741c9a703b2d4c46d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19269922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Theodoridis, Theodoros D.</creatorcontrib><creatorcontrib>Zepiridis, Leonidas</creatorcontrib><creatorcontrib>Zafrakas, Menelaos</creatorcontrib><creatorcontrib>Grimbizis, Grigoris</creatorcontrib><creatorcontrib>Tantsis, Antonios</creatorcontrib><creatorcontrib>Kyrou, Dimitra</creatorcontrib><creatorcontrib>Bontis, John N.</creatorcontrib><title>Levonorgestrel-releasing intrauterine system vs. endometrial thermal ablation for menorrhagia</title><title>Hormones (Athens, Greece)</title><addtitle>Hormones</addtitle><addtitle>Hormones (Athens)</addtitle><description>OBJECTIVE: To evaluate the efficacy of a Levonorgestrel-releasing Intrauterine System (LNG-IUS) in controlling menorrhagia in comparison with endometrial thermal rollerball ablation. DESIGN: Seventy-nine consecutive patients with menorrhagia underwent either LNG-IUS insertion (n=42) or hysteroscopical endometrial thermal rollerball ablation (n=37) in a prospective, observational, comparative study. Women reported duration of uterine bleeding in days prior to, and six and 12 months after each intervention. Prior to each intervention, endometrial, cervical or other pathological conditions of the genital tract were excluded. GnRH analogues for endometrial suppression were given for ten weeks before endometrial ablation but not prior to LNG-IUS insertion. RESULTS: There were no differences in duration of uterine bleeding before each intervention in the two groups. The duration of uterine bleeding was lower in the LNG-IUS group as compared with endometrial ablation at six (p<0.001) and 12 months (p<0.001) after each intervention. Furthermore, the effect on reduction of bleeding was stronger in the LNG-IUS group as compared with the endometrial ablation group at six (p<0.001) and 12 months (p<0.001). CONCLUSIONS: The LNG-IUS was more efficacious than endometrial thermal ablation in reducing duration of uterine bleeding at six and 12 months post-intervention.</description><subject>Endocrinology</subject><subject>Endometrial Ablation Techniques - economics</subject><subject>Female</subject><subject>Humans</subject><subject>Intrauterine Devices, Medicated - economics</subject><subject>Levonorgestrel - administration & dosage</subject><subject>Levonorgestrel - therapeutic use</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menorrhagia - drug therapy</subject><subject>Metabolic Diseases</subject><subject>Prospective Studies</subject><subject>Research Paper</subject><subject>Uterine Hemorrhage - drug therapy</subject><subject>Young Adult</subject><issn>1109-3099</issn><issn>2520-8721</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp1kD1v2zAQhomiQe04mbsVmrrJuSNlUhyLoPkADHRpx4CgqJMtQyJdUgqQf186NtApw-Ed7rkXuIexrwhrrATC3T7Ecc0B-Bo5F5_Ykm84lLXi-JktEUGXArResOuUDgByo2v8whaoudSa8yV72dJr8CHuKE2RhjIP2dT7XdH7Kdp5oth7KtJbmmgsXtO6IN-GkabY26GY9hTHnLYZ7NQHX3QhFiPlvri3u97esKvODoluL7lifx5-_r5_Kre_Hp_vf2xLJ5SayloolCChQdehEJXEFl1NyrUbV1V146SGmneio7ayjarQaatANLytXCVbKVbs-7n3GMPfOb9ixj45GgbrKczJSAUIoFQG786giyGlSJ05xn608c0gmHej5mTUnIyak9F88e1SPTcjtf_5i8IMwBlIeeV3FM0hzNHndz_s_AfhwIPW</recordid><startdate>20090101</startdate><enddate>20090101</enddate><creator>Theodoridis, Theodoros D.</creator><creator>Zepiridis, Leonidas</creator><creator>Zafrakas, Menelaos</creator><creator>Grimbizis, Grigoris</creator><creator>Tantsis, Antonios</creator><creator>Kyrou, Dimitra</creator><creator>Bontis, John N.</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090101</creationdate><title>Levonorgestrel-releasing intrauterine system vs. endometrial thermal ablation for menorrhagia</title><author>Theodoridis, Theodoros D. ; Zepiridis, Leonidas ; Zafrakas, Menelaos ; Grimbizis, Grigoris ; Tantsis, Antonios ; Kyrou, Dimitra ; Bontis, John N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-83716060b1cf133461d1c8e7cd5c448bc69082f3fed4ab741c9a703b2d4c46d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Endocrinology</topic><topic>Endometrial Ablation Techniques - economics</topic><topic>Female</topic><topic>Humans</topic><topic>Intrauterine Devices, Medicated - economics</topic><topic>Levonorgestrel - administration & dosage</topic><topic>Levonorgestrel - therapeutic use</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menorrhagia - drug therapy</topic><topic>Metabolic Diseases</topic><topic>Prospective Studies</topic><topic>Research Paper</topic><topic>Uterine Hemorrhage - drug therapy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Theodoridis, Theodoros D.</creatorcontrib><creatorcontrib>Zepiridis, Leonidas</creatorcontrib><creatorcontrib>Zafrakas, Menelaos</creatorcontrib><creatorcontrib>Grimbizis, Grigoris</creatorcontrib><creatorcontrib>Tantsis, Antonios</creatorcontrib><creatorcontrib>Kyrou, Dimitra</creatorcontrib><creatorcontrib>Bontis, John N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hormones (Athens, Greece)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Theodoridis, Theodoros D.</au><au>Zepiridis, Leonidas</au><au>Zafrakas, Menelaos</au><au>Grimbizis, Grigoris</au><au>Tantsis, Antonios</au><au>Kyrou, Dimitra</au><au>Bontis, John N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Levonorgestrel-releasing intrauterine system vs. endometrial thermal ablation for menorrhagia</atitle><jtitle>Hormones (Athens, Greece)</jtitle><stitle>Hormones</stitle><addtitle>Hormones (Athens)</addtitle><date>2009-01-01</date><risdate>2009</risdate><volume>8</volume><issue>1</issue><spage>60</spage><epage>64</epage><pages>60-64</pages><issn>1109-3099</issn><eissn>2520-8721</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>OBJECTIVE: To evaluate the efficacy of a Levonorgestrel-releasing Intrauterine System (LNG-IUS) in controlling menorrhagia in comparison with endometrial thermal rollerball ablation. DESIGN: Seventy-nine consecutive patients with menorrhagia underwent either LNG-IUS insertion (n=42) or hysteroscopical endometrial thermal rollerball ablation (n=37) in a prospective, observational, comparative study. Women reported duration of uterine bleeding in days prior to, and six and 12 months after each intervention. Prior to each intervention, endometrial, cervical or other pathological conditions of the genital tract were excluded. GnRH analogues for endometrial suppression were given for ten weeks before endometrial ablation but not prior to LNG-IUS insertion. RESULTS: There were no differences in duration of uterine bleeding before each intervention in the two groups. The duration of uterine bleeding was lower in the LNG-IUS group as compared with endometrial ablation at six (p<0.001) and 12 months (p<0.001) after each intervention. Furthermore, the effect on reduction of bleeding was stronger in the LNG-IUS group as compared with the endometrial ablation group at six (p<0.001) and 12 months (p<0.001). CONCLUSIONS: The LNG-IUS was more efficacious than endometrial thermal ablation in reducing duration of uterine bleeding at six and 12 months post-intervention.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>19269922</pmid><doi>10.14310/horm.2002.1223</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Endocrinology Endometrial Ablation Techniques - economics Female Humans Intrauterine Devices, Medicated - economics Levonorgestrel - administration & dosage Levonorgestrel - therapeutic use Medicine Medicine & Public Health Menorrhagia - drug therapy Metabolic Diseases Prospective Studies Research Paper Uterine Hemorrhage - drug therapy Young Adult |
| title | Levonorgestrel-releasing intrauterine system vs. endometrial thermal ablation for menorrhagia |
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