Enhancement of the immune response to residual intrahepatic tumor tissue by laser-induced thermotherapy (LITT) compared to hepatic resection

Background and Objectives In contrast to hepatic resection, thermally destroyed autologous tumor cells remain in situ after laser‐induced thermotherapy (LITT). The aim of the study was to evaluate the effect of LITT and hepatic resection on the immune response to residual intrahepatic tumor tissue a...

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Bibliographic Details
Published in:Lasers in surgery and medicine 2004-10, Vol.35 (4), p.284-292
Main Authors: Isbert, Christoph, Ritz, Jörg-P., Roggan, André, Schuppan, Detlef, Rühl, Martin, Buhr, Heinz J., Germer, Christoph-T.
Format: Article
Language:English
Subjects:
Animals
B7-2
CD8
Hepatectomy
Hyperthermia, Induced
immunohistology
in situ ablation
Laser Therapy
laser-induced thermotherapy
liver metastases
Liver Neoplasms - immunology
Liver Neoplasms - therapy
Male
Neoplasm, Residual - immunology
Rats
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Summary:Background and Objectives In contrast to hepatic resection, thermally destroyed autologous tumor cells remain in situ after laser‐induced thermotherapy (LITT). The aim of the study was to evaluate the effect of LITT and hepatic resection on the immune response to residual intrahepatic tumor tissue and the growth of untreated liver metastases. Study Design/Materials and Methods Two independent adenocarcinomas (CC531) were implanted into 60 WAG rats, one in the right (control tumor) and one in the left liver lobe (treated tumor). The left lobe tumor was treated either by LITT or partial hepatectomy. The control tumor was submitted to further investigation 24 hours, 96 hours, 7 days, and 10 days after treatment. Results Ten days after treatment, control tumor volumes were 296±46 mm_ after LITT and 1,181±192 mm_, 1,387±200 mm_ after hepatic resection and no treatment, respectively (P
ISSN:0196-8092
1096-9101
DOI:10.1002/lsm.20097