2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels

2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide and close analogues inhibit glucose stimulated insulin release through activation of Kir6.2/SUR1 K(ATP) channels of beta cells.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2004-12, Vol.14 (23), p.5727-5730
Main Authors: Nielsen, Flemming E, Jacobsen, Palle, Worsaae, Anne, Arkhammar, Per O G, Wahl, Philip, Bondo Hansen, John
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Animals
ATP-Binding Cassette Transporters - agonists
ATP-Binding Cassette Transporters - metabolism
Benzamides - chemistry
Benzamides - pharmacology
Benzothiadiazines - chemistry
Benzothiadiazines - pharmacology
Diazoxide - analogs & derivatives
Diazoxide - chemistry
Diazoxide - pharmacology
Islets of Langerhans - drug effects
Islets of Langerhans - metabolism
Potassium Channels - agonists
Potassium Channels - metabolism
Potassium Channels, Inwardly Rectifying - agonists
Potassium Channels, Inwardly Rectifying - metabolism
Pyridines - chemistry
Pyridines - pharmacology
Rats
Receptors, Drug - agonists
Receptors, Drug - metabolism
Sulfonylurea Receptors
Thiadiazines - chemistry
Thiadiazines - pharmacology
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Description
Summary:2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide and close analogues inhibit glucose stimulated insulin release through activation of Kir6.2/SUR1 K(ATP) channels of beta cells.
ISSN:0960-894X
1464-3405