Does autonomic neuropathy play a role in erythropoietin regulation in non-proteinuric Type 2 diabetic patients?

Aims  Erythropoietin (EPO)‐deficient anaemia has been described in Type 1 diabetic patients with both severe autonomic neuropathy (AN) and proteinuria. This study was aimed at distinguishing between the effects of AN and nephropathy on haemoglobin and EPO levels in Type 2 diabetic patients at an ear...

Full description

Saved in:
Bibliographic Details
Published in:Diabetic medicine 2004-11, Vol.21 (11), p.1174-1180
Main Authors: Spallone, V., Maiello, M. R., Kurukulasuriya, N., Barini, A., Lovecchio, M., Tartaglione, R., Mennuni, G., Menzinger, G.
Format: Article
Language:English
Subjects:
Adult
Aged
Albuminuria - blood
anaemia
Autonomic Nervous System Diseases - blood
autonomic neuropathy
Biological and medical sciences
Blood Pressure
Diabetes Mellitus, Type 2 - blood
Diabetes. Impaired glucose tolerance
Diabetic Nephropathies - blood
Diabetic Neuropathies - blood
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
erythropoietin
Erythropoietin - blood
Female
Hemoglobins - metabolism
Humans
Hypotension, Orthostatic - blood
kidney function
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Type 2 diabetes
Urinary system involvement in other diseases. Miscellaneous
Urinary tract. Prostate gland
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims  Erythropoietin (EPO)‐deficient anaemia has been described in Type 1 diabetic patients with both severe autonomic neuropathy (AN) and proteinuria. This study was aimed at distinguishing between the effects of AN and nephropathy on haemoglobin and EPO levels in Type 2 diabetic patients at an early stage of diabetic nephropathy. Methods  In 64 Type 2 diabetic patients (age 52 ± 10 years, duration 10 ± 9 years) without overt nephropathy and other causes of anaemia or EPO deficit, we assessed cardiovascular tests of AN, 24‐h blood pressure (BP) monitoring, urinary albumin excretion rate (UAE), a full blood count, and serum EPO. Results  Although the Type 2 diabetic patients with AN did not show differences in haemoglobin and EPO when compared with patients without AN, the presence of haemoglobin
ISSN:0742-3071
1464-5491
DOI:10.1111/j.1464-5491.2004.01306.x