Lymphatic vessel density is significantly increased in melanoma

Background:  Melanoma is well known for its ability to involve regional lymph nodes in the early stage. However, the presence of lymphangiogenesis in melanoma is still controversial due to lack of lymphatic‐specific markers. The purpose of this study was to determine the intra‐ and peritumoral lymph...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2004-11, Vol.31 (10), p.672-677
Main Authors: Giorgadze, T. A., Zhang, P. J., Pasha, T., Coogan, P. S., Acs, G., Elder, D. E., Xu, X.
Format: Article
Language:English
Subjects:
Antibodies, Monoclonal - immunology
Biological and medical sciences
Biomarkers - metabolism
Dermatology
Humans
Immunoenzyme Techniques
Lymphatic Vessels - metabolism
Lymphatic Vessels - pathology
Medical sciences
Melanoma - blood supply
Melanoma - pathology
Neovascularization, Pathologic
Nevus - blood supply
Nevus - metabolism
Nevus - pathology
Platelet Endothelial Cell Adhesion Molecule-1 - metabolism
Precancerous Conditions - blood supply
Precancerous Conditions - metabolism
Precancerous Conditions - pathology
Skin Neoplasms - blood supply
Skin Neoplasms - pathology
Tumors of the skin and soft tissue. Premalignant lesions
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Summary:Background:  Melanoma is well known for its ability to involve regional lymph nodes in the early stage. However, the presence of lymphangiogenesis in melanoma is still controversial due to lack of lymphatic‐specific markers. The purpose of this study was to determine the intra‐ and peritumoral lymphatic vessel density (LVD) using a novel lymphatic vessel‐specific marker D2‐40 and compare it to general vessel density (GVD) as determined by CD31 immunostaining in a series of melanocytic lesions. Methods:  The intra‐ and peritumoral GVD and LVD were examined by immunohistochemistry using D2‐40 and CD31 antibodies in a series of melanocytic lesions. Results:  We found significantly higher intratumoral LVD in melanomas as compared to either common acquired or dysplastic nevi (p 
ISSN:0303-6987
1600-0560
DOI:10.1111/j.0303-6987.2004.00249.x