Looking through ion channels: recharged concepts in T-cell signaling

It has been suggested that lymphocyte K + and Ca 2+ channels participate in the early phase of T-cell activation by generating a Ca 2+ signal to drive T-cell proliferation. Recent biophysical and pharmacological characterization of ion channels responsible for Ca 2+ entry into cells facilitated a be...

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Bibliographic Details
Published in:Trends in immunology 2004-11, Vol.25 (11), p.565-569
Main Authors: Panyi, György, Vámosi, György, Bodnár, Andrea, Gáspár, Rezső, Damjanovich, Sándor
Format: Article
Language:English
Subjects:
Calcium - metabolism
Gene expression
Genotype & phenotype
Humans
Immune system
Ion Channels - metabolism
Kinases
Lymphocytes
Multiple Sclerosis - metabolism
Proteins
Rodents
T cell receptors
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
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Summary:It has been suggested that lymphocyte K + and Ca 2+ channels participate in the early phase of T-cell activation by generating a Ca 2+ signal to drive T-cell proliferation. Recent biophysical and pharmacological characterization of ion channels responsible for Ca 2+ entry into cells facilitated a better understanding of the physiological role of these channels. In addition, the simple ‘permissive’ function of ion channels in T-cell activation has been challenged recently, by studies indicating that pharmacological tools can selectively inhibit pathological immune reactions, and voltage-gated K + channels might directly participate in the function of the immunological synapse.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2004.09.002