Search for Serum Biomarkers Associated with Abdominal Aortic Aneurysm Growth – A Pilot Study

Abstract Introduction Serological biomarkers could reflect asymptomatic infrarenal aortic aneurysm (AAA) activity and guide patient management. Report Serum concentrations of C-reactive protein (CRP), alpha 1-antitrypsin and lipoprotein(a) were measured in blood samples from 35 AAA patients and 35 c...

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Bibliographic Details
Published in:European journal of vascular and endovascular surgery 2009-03, Vol.37 (3), p.297-299
Main Authors: Vega de Céniga, M, Esteban, M, Quintana, J.M, Barba, A, Estallo, L, de la Fuente, N, Viviens, B, Martin-Ventura, J.L
Format: Article
Language:English
Subjects:
Abdominal aortic aneurysm
Aged
Aged, 80 and over
Alpha 1-antitrypsin
alpha 1-Antitrypsin - blood
Aortic Aneurysm, Abdominal - blood
Aortic Aneurysm, Abdominal - pathology
Biomarkers - blood
C-Reactive Protein - analysis
Case-Control Studies
CRP
Female
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Lipoprotein(a)
Lipoprotein(a) - blood
Male
Middle Aged
Multivariate Analysis
Pilot Projects
Serum biomarkers
Surgery
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Summary:Abstract Introduction Serological biomarkers could reflect asymptomatic infrarenal aortic aneurysm (AAA) activity and guide patient management. Report Serum concentrations of C-reactive protein (CRP), alpha 1-antitrypsin and lipoprotein(a) were measured in blood samples from 35 AAA patients and 35 controls and correlated with the aortic diameter and AAA growth in the previous 12 months. We found a positive correlation between CRP and AAA diameter ( r = 0.46; p = 0.007) and alpha 1-antitrypsin and AAA growth ( r = 0.55; p = 0.004). Conclusions Alpha 1-antitrypsin may be a promising biomarker of AAA growth.
ISSN:1078-5884
1532-2165
DOI:10.1016/j.ejvs.2008.11.014