Quantitative analysis of foot-and-mouth disease virus RNA duration in tissues of experimentally infected pigs

Quantitative analysis of the duration of foot-and-mouth disease virus (FMDV) RNA in tissues was carried out in pigs experimentally infected with FMDV O UKG 34/2001 and O SKR 1/2000. The results showed that the viral RNA was still detectable in cervical lymph nodes, mandibular lymph nodes and tonsils...

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Bibliographic Details
Published in:The veterinary journal (1997) 2009-04, Vol.180 (1), p.130-132
Main Authors: Zhang, Zhidong, Bashiruddin, John B.
Format: Article
Language:English
Subjects:
animal tissues
Animals
detection
Female
FMD
Foot-and-mouth disease
Foot-and-Mouth Disease - virology
Foot-and-mouth disease virus
Foot-and-Mouth Disease Virus - isolation & purification
Foot-and-Mouth Disease Virus - pathogenicity
lymph nodes
Lymph Nodes - virology
microbial genetics
Palate, Soft - virology
Palatine Tonsil - virology
Persistence
Pharynx - virology
Real-time RT-PCR
RNA
RNA, Viral - analysis
Swine
swine diseases
Swine Diseases - virology
temporal variation
Time Factors
viral persistence
Viremia - veterinary
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Summary:Quantitative analysis of the duration of foot-and-mouth disease virus (FMDV) RNA in tissues was carried out in pigs experimentally infected with FMDV O UKG 34/2001 and O SKR 1/2000. The results showed that the viral RNA was still detectable in cervical lymph nodes, mandibular lymph nodes and tonsils collected from both inoculated and contact pigs at 28 days post infection. There was no detectable viral RNA in the soft palate or pharynx, which are thought to be tissue sites for viral persistence in cattle. Further study is needed to clarify whether this difference has significance in terms of viral clearance in pigs.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2007.11.010