Gastrointestinal stromal tumors (GISTs): a review

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms in the gastrointestinal tract, which, over the last 10 years, have emerged from a poorly understood neoplasm to a well-defined tumor entity exhibiting particular molecular abnormalities and for which promising novel tr...

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Bibliographic Details
Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2009-02, Vol.117 (2), p.73-86
Main Authors: STEIGEN, SONJA E, EIDE, TOR J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Gastrointestinal stromal tumors
Gastrointestinal Stromal Tumors - diagnosis
Gastrointestinal Stromal Tumors - genetics
Gastrointestinal Stromal Tumors - pathology
Gastrointestinal Stromal Tumors - therapy
Humans
Infectious diseases
interstitial cells of Cajal
Medical sciences
Microbiology
Mutation
mutations
Positron-Emission Tomography
Prognosis
Proto-Oncogene Proteins c-kit - genetics
Proto-Oncogene Proteins c-kit - metabolism
Tomography, X-Ray Computed
Tumors
tyrosine kinase
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Summary:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms in the gastrointestinal tract, which, over the last 10 years, have emerged from a poorly understood neoplasm to a well-defined tumor entity exhibiting particular molecular abnormalities and for which promising novel treatment modalities have been developed. GISTs probably arise from the precursor cell of the interstitial cell of Cajal, express KIT tyrosine kinase in most of the cases and harbor mutations of importance for individualized treatment. The molecular targets for therapeutic interventions are not only of importance for the treatment of GIST patients but also useful for in the development of novel drug modalities and new strategies in basic cancer therapy.
ISSN:0903-4641
1600-0463
DOI:10.1111/j.1600-0463.2008.00020.x