Smell testing is abnormal in ‘lubag’ or X-linked dystonia-parkinsonism: a pilot study

We administered a culturally corrected University of Pennsylvania Smell Identification Test (ccUPSIT) consisting of 25 odor items to 20 patients with ‘Lubag’ or X-linked dystonia-parkinsonism and 20 control subjects matched by sex, age, educational background, smoking history, and geographical origi...

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Bibliographic Details
Published in:Parkinsonism & related disorders 2004-10, Vol.10 (7), p.407-410
Main Authors: Evidente, Virgilio Gerald H., Esteban, Raymund P., Hernandez, Jose Luis, Natividad, Filipinas F., Advincula, Joel, Gwinn-Hardy, Katrina, Hardy, John, Singleton, Amanda, Singleton, Andrew
Format: Article
Language:English
Subjects:
Adult
Dystonia - diagnosis
Dystonia - genetics
Genetic Diseases, X-Linked - diagnosis
Genetic Diseases, X-Linked - genetics
Humans
Lubag
Male
Middle Aged
Odorants
Olfaction
Parkinson Disease - diagnosis
Parkinson Disease - genetics
Pilot Projects
Smell - genetics
X-linked dystonia parkinsonism
XDP
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Summary:We administered a culturally corrected University of Pennsylvania Smell Identification Test (ccUPSIT) consisting of 25 odor items to 20 patients with ‘Lubag’ or X-linked dystonia-parkinsonism and 20 control subjects matched by sex, age, educational background, smoking history, and geographical origin. The mean ccUPSIT score of Lubag patients (18±3.19) was statistically lower ( P=0.003) than controls (20.5±3.02). The smell scores did not correlate with phenotype, severity of dystonia, or duration of disease. Nine of 20 Lubag patients (45%) had ccUPSIT scores below the mean, with the lowest score being 11. This pilot study suggests that olfactory dysfunction may occur in Lubag patients.
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2004.04.011