Effect of sighs on breathing memory and dynamics in healthy infants

1 Pediatric Respiratory Medicine, University Children's Hospital, Bern 3010, Switzerland; 2 Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215; and 3 Clinical Sciences Division, Institute for Child Health and Centre for Child Health Research, University of West...

Full description

Saved in:
Bibliographic Details
Published in:Journal of applied physiology (1985) 2004-11, Vol.97 (5), p.1830-1839
Main Authors: Baldwin, D. N, Suki, B, Pillow, J. J, Roiha, H. L, Minocchieri, S, Frey, U
Format: Article
Language:English
Subjects:
Babies
Biological and medical sciences
Carbon Dioxide
Cardiorespiratory control. Arterial mecano- and chemoreceptor
Cross-Sectional Studies
Exhalation
Feedback, Physiological
Fundamental and applied biological sciences. Psychology
Health
Humans
Infant
Infant, Newborn - physiology
Lungs
Oxygen
Reference Values
Respiratory Mechanics
Respiratory Physiological Phenomena
Respiratory system
Tidal Volume
Vertebrates: respiratory system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:1 Pediatric Respiratory Medicine, University Children's Hospital, Bern 3010, Switzerland; 2 Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215; and 3 Clinical Sciences Division, Institute for Child Health and Centre for Child Health Research, University of Western Australia, Perth 6008, Australia Submitted 18 March 2004 ; accepted in final form 16 June 2004 Deep inspirations (sighs) play a significant role in altering lung mechanical and airway wall function; however, their role in respiratory control remains unclear. We examined whether sighs act via a resetting mechanism to improve control of the respiratory regulatory system. Effects of sighs on system variability, short- and long-range memory, and stability were assessed in 25 healthy full-term infants at 1 mo of age [mean 36 (range 28–57) days] during quiet sleep. Variability was examined using moving-window coefficient of variation, short-range memory using autocorrelation function, and long-range memory using detrended fluctuation analysis. Stability was examined by studying the behavior of the attractor with use of phase-space plots. Variability of tidal volume (V T ) and minute ventilation ( E ) increased during the initial 15 breaths after a sigh. Short-range memory of V T decreased during the 50 breaths preceding a sigh, becoming uncorrelated (random) during the 10-breath presigh window. Short-range memory increased after a sigh for the entire 50 breaths compared with the randomized data set and for 20 breaths compared with the presigh window. Similar, but shorter duration, changes were noted in E . No change in long-range memory was seen after a sigh. Coefficient of variation and range of points located within a defined attractor segment increased after a sigh. Thus control of breathing in healthy infants shows long-range stability and improvement in short-range memory and variability after a sigh. These results add new evidence that the role of sighs is not purely mechanical. nonlinear dynamics; feedback; control; systems theory Address for reprint requests and other correspondence: D. N. Baldwin, Pediatric Respiratory Medicine, Univ. Children's Hospital of Berne, Berne CH-3010, Switzerland (E-mail: dn_baldwin{at}hotmail.com ).
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.00298.2004