Synthesis and biological activity of anticoccidial agents: 2,3-diarylindoles

In this study, we present the synthesis and biological activity of 2,3-diarylindoles, whose antiparasitic activity against Eimeria is due to inhibition of a parasite specific cGMP-dependent protein kinase (PKG). From this series, several compounds showed subnanomolar in vitro activity and significan...

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Bibliographic Details

Published in:	Bioorganic & medicinal chemistry letters 2009-03, Vol.19 (5), p.1517-1521
Main Authors:	Scribner, Andrew, Moore, Joseph A., Ouvry, Gilles, Fisher, Michael, Wyvratt, Matthew, Leavitt, Penny, Liberator, Paul, Gurnett, Anne, Brown, Chris, Mathew, John, Thompson, Donald, Schmatz, Dennis, Biftu, Tesfaye
Format:	Article
Language:	eng
Subjects:	Animals Anticoccidial Antiparasitic Antiprotozoan Coccidiosis - drug therapy Coccidiosis - enzymology Coccidiosis - parasitology Coccidiostats - chemical synthesis Coccidiostats - pharmacology Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors Eimeria tenella - drug effects Eimeria tenella - enzymology Eimeria tenella - growth & development Indole Indoles - chemical synthesis Indoles - pharmacology Kinase inhibitor Poultry - parasitology Protien kinase G Pyridines - chemical synthesis
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