Individual effect-site concentrations of propofol at return of consciousness are related to the concentrations at loss of consciousness and age in neurosurgical patients

Abstract Study Objective To investigate whether a patient's propofol effect-site concentration at return to consciousness (ROC) was related to the propofol effect-site concentration at loss of consciousness (LOC) and to patients' individual demographic parameters. Design Prospective study....

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Bibliographic Details
Published in:Journal of clinical anesthesia 2009-02, Vol.21 (1), p.3-8
Main Authors: Nunes, Catarina S, Ferreira, David A, Antunes, Luís, Lobo, Francisco, Santos, Isabel A, Amorim, Pedro
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Analgesics
Anesthesia
Anesthesia & Perioperative Care
Anesthesia Recovery Period
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthetics, Intravenous - pharmacokinetics
Anesthetics, Intravenous - therapeutic use
Biological and medical sciences
Consciousness
Consciousness - drug effects
Consciousness, loss of
Consciousness, return to
Drug dosages: effect-site concentrations
Drug Therapy, Combination
Female
Humans
Male
Medical sciences
Middle Aged
Neurosurgical Procedures - methods
Pain Medicine
Piperidines - pharmacokinetics
Piperidines - therapeutic use
Plasma
Propofol - pharmacokinetics
Propofol - therapeutic use
Propofol, hypnotic dose
Prospective Studies
Surgery
Young Adult
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Summary:Abstract Study Objective To investigate whether a patient's propofol effect-site concentration at return to consciousness (ROC) was related to the propofol effect-site concentration at loss of consciousness (LOC) and to patients' individual demographic parameters. Design Prospective study. Setting Operating room. Patients 31 ASA physical status I and II neurosurgical patients with Glasgow Coma Score > 15, and scheduled to receive total intravenous anesthesia with effect-site target controlled infusion (TCI) of propofol and remifentanil. Interventions A constant propofol infusion was administered until LOC. At LOC, remifentanil started with a plasma concentration target of 2.5 ng mL−1. Main Results Propofol concentration at LOC was 4.9 ± 1 μ g mL−1 . At ROC, propofol and remifentanil concentrations were 1.16 ± 0.3 μ g mL−1 and 3.41 ± 1.5 ng mL−1 . Significant correlation was observed between propofol concentrationa at ROC and LOC, between propofol concentration at ROC and patient age (48.7 ± 15 yrs), and between propofol concentrations at ROC and LOC, divided by patient's age. Conclusions The correlation between propofol concentrations at ROC and LOC was improved by inclusion of patient age data.
ISSN:0952-8180
1873-4529
DOI:10.1016/j.jclinane.2008.06.011