Design of Temperature Sensitive Imprinted Polymer Hydrogels Based on Multiple-Point Hydrogen Bonding

Weakly cross‐linked temperature sensitive imprinted polymer hydrogels that recognize L‐pyroglutamic acid (Pga) molecules via multiple‐point hydrogen bonding were designed and synthesized. The amount of adsorption for Pga in imprinted hydrogels is 3–4 times higher than that in non‐imprinted hydrogels...

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Bibliographic Details
Published in:Macromolecular bioscience 2004-07, Vol.4 (7), p.680-684
Main Authors: Liu, Xue-Yong, Guan, Ying, Ding, Xiao-Bin, Peng, Yu-Xing, Long, Xin-Ping, Wang, Xiao-Chuan, Chang, Kun
Format: Article
Language:English
Subjects:
Adsorption
Applied sciences
Exact sciences and technology
Hydrogels - chemical synthesis
Hydrogels - chemistry
Hydrogen Bonding
Hydrogen-Ion Concentration
L-pyroglutamic acid
molecular imprinted polymer
molecular imprinting
Organic polymers
Physicochemistry of polymers
Proline - chemistry
Properties and characterization
Pyrrolidines - chemistry
Pyrrolidinones - chemistry
Solution and gel properties
Substrate Specificity
Temperature
temperature sensitive
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Summary:Weakly cross‐linked temperature sensitive imprinted polymer hydrogels that recognize L‐pyroglutamic acid (Pga) molecules via multiple‐point hydrogen bonding were designed and synthesized. The amount of adsorption for Pga in imprinted hydrogels is 3–4 times higher than that in non‐imprinted hydrogels. The selectivity test of imprinted polymer gels was carried out by using a series of structurally related compounds Pga, pyrrolidine, 2‐pyrrolidone, L‐proline as substrates. The results show that imprinted polymer gels exhibit high selectivity for Pga as compared to all the other tested substrates. The imprinted polymer hydrogels show good temperature sensitivity, special selectivity and reusability, suggesting that the polymer hydrogels would have an enormous potential for application in controlled drug release and separation field. Schematic representation of the adsorption and release process of Pga by the imprinted polymeric gels.
ISSN:1616-5187
1616-5195
DOI:10.1002/mabi.200400031